The development of congestive heart failure (CHF) is associated with left ventricle (LV) dilation and myocardial remodeling. The matrix metalloproteinases (MMPs) play a significant role in extracellular remodeling, and recent studies have demonstrated increased MMP expression and activity with CHF. Whether increased MMP activity directly contributes to the LV remodeling with CHF remains unknown...

The Minnesota Multiphasic Personality Inventory-2 is a broadband measure of psychopathology and personality that has a long tradition in assessment of medical patients. Beginning in the 1940’s the MMPI was used in the study of psychological factors in medical conditions and an extensive research base for the MMPI, and its successor the MMPI-2, in medical applications has developed. The current ...

In this comment, I address a number of the points raised in the reviews of the MMPI-2 Restructured Clinical (RC; Tellegen et al., 2003) Scales by Nichols (2006/this issue) and Rogers, Sewell, Harrison, and Jordan (2006/this issue), and I advocate for changes in assessment validation research. There is little evidence that the "syndromal complexity" Nichols ascribes to the original MMPI-2 (Butch...

Two previous meta-analyses concluded that average validity coefficients for the Rorschach and the MMPI have similar magnitudes (L. Atkinson, 1986; K. C. H. Parker, R. K. Hanson, & J. Hunsley, 1988), but methodological problems in both meta-analyses may have impeded acceptance of these results (H. N. Garb, C. M. Florio, & W. M. Grove, 1998). We conducted a new meta-analysis comparing criterionre...

The current study investigates the extent to which the Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) profiles of 196 male adolescents evaluated in a South Carolina detention center could be successfully discriminated from the protocols of 200 male adolescent psychiatric inpatients in three states and 151 dually diagnosed male adolescents. Results showed significant differences...

Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) treatment is effective for the treatment of primary tumors, but not sufficient for the treatment of metastatic tumors, likely owing to the effects of the tumor microenvironment. In this study, we aimed to determine the therapeutic effects of combined treatment with a matrix metalloproteinase (MMP) inhibitor (MMPI) and anti-CTLA-4 antibody in a brea...

Previous research has suggested that except for paranoid schizophrenics, similarity in diagnostic category has little effect on sociometric choice among patients. A sociometric study was conducted employing MMPI scales as well as diagnostic categories on 84 hospitalized psychiatric patients. When diagnostic labels from the patients' charts were used, results showed no relationship between socio...

Although PTSD-S was developed in 1987, it was evolved using the MMPI-2. The 53-item subset for the MMPI is presented in tabular form.

Users of multi-scale tests like the MMPI-2 tend not to interpret scales one at a time in a way that would correspond to standard scale-level reliability information. Instead, clinicians integrate inferences from a multitude of scales simultaneously, producing a descriptive narrative that is thought to characterize the examinee. This study was an attempt to measure the reliability of such integr...