نتایج جستجو برای: modified bet
تعداد نتایج: 259095 فیلتر نتایج به سال:
Malignant brain tumors are the most common solid tumors in children. The overall prognosis for this group of patients is still poor, emphasizing the importance of more effective therapies. Betulinic acid (Bet A) has been described as a novel cytotoxic compound active against melanoma and neuroblastoma cells. Here we report that Bet A was active against medulloblastoma and glioblastoma cell line...
The basic principles of Bounded Exhaustive Testing (BET) are reviewed, as well as the concept of an Elusive Bug (EB). Initial work on the application of BET to EB's previously indicated that it provides a new and promising approach to this problem. A four-part BET/EB oriented test framework involving: fault model development, BET test generation design, failure model identification and automate...
The transcription factor T-bet regulates the production of interferon-γ and cytotoxic molecules in effector CD8 T cells, and its expression correlates with improved control of chronic viral infections. However, the role of T-bet in infections with differential outcome remains poorly defined. Here, we report that high expression of T-bet in virus-specific CD8 T cells during acute hepatitis B vir...
Introduction: Ethylbenzene is a volatile organic compound used in many industries, including oil and gas, oil colored and insecticides. Due to the toxic effects of this chemical substance, control and elimination of this vapor is necessary. Photocatalytic degradation is a possible method to remove organic compounds from air. This study was performed to determine the efficiency of photocatalytic...
مقدار تبخیر و تعرق حقیقی مزرعه یونجه واقع در باجگاه بوسیله روش تعادل آبیاری در 9 کرت آزمایشی و دولیسمتر از نوع وزنی بمنظور تعیین آب مصرفی گیاه یونجه تعیین شد. در طول مدت آزمایش مقدار آب موجود در خاک بوسیله نمونه برداری وزنی از خاک و دستگاه نوترون متر تعیین و مقدار تشعشع رسیده از خورشید بزمین و ساعات آفتابی روز نیز اندازه گیری شد. مقدار تبخیر و تعرق پتانسیل بوسیله روشهای modified blaney-criddle ...
Despite the recognized role of the T-bet transcription factor in the differentiation of Th1 cells, T-bet-deficient mice can develop small numbers of IFN-gamma-producing CD4 T cells. Although these are not sufficient to allow normal handling of some pathogens, T-bet-deficient mice do resolve infection with the intracellular pathogen Listeria monocytogenes. In contrast, we report that expression ...
Pancreatic ductal adenocarcinoma (PDAC) is associated with pronounced fibrosis that contributes to chemoresistance, in part, through increased histone acetylation. Because bromodomain (BRD) and extra terminal domain (BET) proteins are "readers" of histone acetylation marks, we targeted BET proteins in PDAC cells grown in three-dimensional collagen. We show that treatment with BET inhibitors dec...
The transcription factor T-bet regulates the differentiation of CD4(+) T-helper type 1 (Th1) cells and represses Th2 lineage commitment. Since Th1 cells are crucial in the defense against pathogens, several studies addressed the role of T-bet in immunity to infection using T-bet knockout (T-bet(-/-)) mice. Nevertheless, it is still unclear whether T-bet is required for defense. Although vaccini...
T-bet is a transcription factor that is essential for T helper (Th)1 lineage commitment and optimal IFN-gamma production by CD4(+) T cells. We examined the role of T-bet in the development of experimental crescentic glomerulonephritis, which is induced by Th1-predominant, delayed-type hypersensitivity-like responses directed against a nephritogenic antigen. Anti-glomerular basement membrane (GB...
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