BACKGROUND AND PURPOSE A change in acute-to-chronic lesion volume has been proposed as a biomarker for stroke therapies. The objectives of this study were to determine the magnitude of lesion volume change after standard treatment with tissue plasminogen activator and to determine whether specific volume change thresholds can discriminate clinical responders from nonresponders. METHODS We mea...

OBJECTIVE To review our surgical experience in minimally invasive transcranial endoscope-assisted microsurgical treatment of intracranial aneurysms, using the supraorbital keyhole craniotomy. METHODS The supraorbital keyhole approach was performed through an eyebrow skin incision in 793 cases for treatment of 989 intracranial aneurysms. Of patients, 474 were operated on after subarachnoid hem...

BACKGROUND AND PURPOSE Argatroban, a selective thrombin inhibitor, is recommended for the use in patients with atherothrombotic stroke by the Japanese Guidelines for the Management of Patients with Acute Ischemic Stroke. We performed a nationwide Japanese study to investigate whether argatroban improved early stroke outcomes in patients with acute atherothrombotic stroke. METHODS This retrosp...

Background and Purpose—There is debate regarding the approach for analysis of modified Rankin scale scores, the most common functional outcome scale used in acute stroke trials. Methods—We propose to use tests to assess treatment differences addressing the metric, “if a patient is chosen at random from each treatment group and if they have different outcomes, what is the chance the patient who ...

BACKGROUND AND PURPOSE There is debate regarding the approach for analysis of modified Rankin scale scores, the most common functional outcome scale used in acute stroke trials. METHODS We propose to use tests to assess treatment differences addressing the metric, "if a patient is chosen at random from each treatment group and if they have different outcomes, what is the chance the patient wh...

Background and Purpose—We sought to assess the psychometric attributes of the Brazilian version of the Stroke Impact Scale (SIS) 3.0 in stroke survivors. Methods—Patients were evaluated by the National Institutes of Health Stroke Scale, Mini-Mental State Examination, Barthel Index, Lawton Instrumental Activities of Daily Living Scale, modified Rankin Scale, Geriatric Depression Scale, and Hospi...

BACKGROUND AND PURPOSE The purpose of this study was to determine the accuracy and optimal timing of physician prognostication in patients with subarachnoid hemorrhage, a prototypical neurological disease characterized by variable outcomes and frequent disability. METHODS From October 2009 to April 2010, treating neurologists at a tertiary care academic medical center made daily predictions o...

[Purpose] The study aimed to characterize patients treated by rehabilitation section after establishment of an acute stroke unit. [Subjects and Methods] Medical consultation records of individuals with ischemic stroke were studied retrospectively, excluding individuals with hemorrhagic stroke, thrombolysis, previous Modified Rankin Scale ≥ 1, prior stroke, structural bone deformities, associate...

BACKGROUND AND PURPOSE We sought to assess the psychometric attributes of the Brazilian version of the Stroke Impact Scale (SIS) 3.0 in stroke survivors. METHODS Patients were evaluated by the National Institutes of Health Stroke Scale, Mini-Mental State Examination, Barthel Index, Lawton Instrumental Activities of Daily Living Scale, modified Rankin Scale, Geriatric Depression Scale, and Hos...