This study determined whether phosphodiesterase (PDE) was activated by protein kinase C (PKC) upon kappa-receptor stimulation, and if so, to identify the isozyme. We first studied the effects of trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl] cyclohexyl) benzeneacetamide methanesulphonate (U50,488H), a selective kappa-opioid receptor (OR) agonist, and phorbol-12-myristate-13-acetate (PM...

The aim of this paper is to solve numerically the Cauchy problems nonlinear partial differential equation (PDE) in a modified variational iteration approach. standard method (VIM) first studied before modifying it using Adomian polynomials decomposing terms PDE attain new iterative scheme (MVIM). VIM was used iteratively determine parabolic obtain some results. Also, PDEs with aid Maple 18 soft...

Recently, a rigorous mathematical theory has been developed for spatial games with weak selection, i.e., when the payoff differences between strategies are small. The key to the analysis is that when space and time are suitably rescaled, the spatial model converges to the solution of a partial differential equation (PDE). This approach can be used to analyze all [Formula: see text] games, but t...

The level of phosphodiesterase (PDE) activity is lower in collagenase-isolated human fat cells than in adipose tissue fragments. The inhibition is not species-specific since collagenase also inhibits PDE in rat adipose tissue and bovine heart. In subcellular fractions from isolated fat cells, the PDE activities were lowest in the plasma membrane-enriched fractions and highest in the cytosolic f...

We study a class of variational problems for regularized conservation laws with Lax's entropy-entropy flux pairs. first introduce modified optimal transport space based on diffusion. Using this space, we demonstrate that diffusion are “flux–gradient flows”. next construct these flows, which derive dual PDE systems laws. Several examples, including traffic flow and Burgers' equation, presented. ...

Oscillatory yeast cell dynamics are observed in glucose-limited growth environments. Under such conditions, both glucose and the excreted product ethanol can serve as substrates for cell growth. The cell dynamics is described by a PDE (partial differential equation) system containing one PDE for the cell population and 8 ODEs for 8 substrates variations (extracellular glucose, extracellular eth...

In 1988, Parker and Sochacki announced a theorem which proved that the Picard iteration, properly modified, generates the Taylor series solution to any ordinary differential equation (ODE) on n with a polynomial generator. In this paper, we present an analogous theorem for partial differential equations (PDEs) with polynomial generators and analytic initial conditions. Since the domain of a sol...

BACKGROUND Millions of men around the world suffer from erectile dysfunction, for which phosphodiesterase 5 inhibitors (PDE-5 inhibitors) are currently the first treatment option. Sexual activity and alcohol consumption are closely related, and the simultaneous use of alcohol and PDE-5 inhibitors can happen. Lodenafil carbonate is a new PDE-5 inhibitor, developed by a Brazilian pharmaceutical c...

Exposure of perfused rat lungs to lipopolysaccharides (LPS) causes induction of cyclooxygenase-2 followed by thromboxane (TX)-mediated bronchoconstriction (BC). Recently, phosphodiesterase (PDE) inhibitors have received much interest because they not only are bronchodilators but also can suppress release of proinflammatory mediators. In the present study, we investigated the effect of three dif...