Cancer Drug Resistance is an open access journal, focusing on pharmacological aspects of drug resistance and its reversal, molecular mechanisms classes, etc. Both clinical experimental in cancer are included.

the characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. in this report we characterise a leukemic model, d5a1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. cells induced with 4 mm hexamethylene bisacetamide (hmba) caused signs...

Scientific progress in the biological sciences increasingly relies on an integration of behavioral, pharmacological, cellular, and molecular approaches, particularly in translating basic research observations into therapeutic potential. The strength of in vivo model systems lies in the direct assessment of physiological function. However, they only allow indirect evidence for mechanism of actio...

Glucocorticoids are the most effective therapy for the treatment of many chronic infl ammatory diseases such as asthma and infl ammatory bowel disease (Ito et al., 2006a). In contrast to the situation in asthma, chronic obstructive pulmonary disease (COPD), a common and debilitating chronic infl ammatory disease of the lung, is glucocorticoid insensitive (Barnes, 2000a, b; Culpitt et al., 2003)...

Anemoside B4 (AB4), as an important ingredient of Chinese herb Pulsatilla Chinensis, has been used in ancient medicine for thousands years with exact therapeutic effects anti-inflammation and anti-tumor. Due to its high potency low toxicity, AB4 caused more attention researchers. In this paper, our article reviews the research progress on pharmacological actions molecular mechanisms order provi...