Earlier studies have shown that transferrin-gallium inhibits cellular iron incorporation and blocks DNA synthesis by decreasing the activity of the iron-dependent M2 subunit of ribonucleotide reducÃ-ase.We ex amined the growth-inhibitory effects of gallium nitrate in combination with clinically relevant inhibitors of ribonucleotide reducÃ-asefludarabine (an Ml subunit inhibitor), and iron chela...

BACKGROUND Diagnosis of active pulmonary and paranasal involvement in patients with Wegener's granulomatosis (WG) can be difficult. The diagnostic value of gallium-67 scintigraphy in WG is unclear. OBJECTIVE To evaluate the added diagnostic value of gallium-67 scintigraphy in patients with WG with suspected granulomatous inflammation in the paranasal and chest regions. METHODS Retrospective...

The growth inhibitory effects of gallium on a murine and human B-cell line were studied using two different serum-free culture systems: (a) ferric citrate medium containing 500 microM iron and (b) transferrin medium containing 5 micrograms/ml of iron-saturated transferrin (0.125 microM iron). For the human cell line in ferric citrate medium, 50% growth inhibition achieved in the presence of tra...

In the thermal spraying process, the process for the molten metal particles to hit against matrix to form coating experiences great change temperature. Since the coating materials has different thermal physical properties with the matrix materials, the residual stress is surely left in the coating. Much bigger residual stress not only restricts coating thickness but also primarily affects coati...

Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for the study of the structure, dynamics, and folding of proteins in solution. It is particularly powerful when applied to dynamic or flexible systems, such as partially folded molten globule states of proteins, which are not usually amenable to X-ray crystallography. In this article, NMR methods suitable for the detailed cha...

Z. Naturforsch. 56 b, 458^462 (2001); received April 4, 2001 Gallium(III) and Gallium(II) Amides, Gallium Amino Complexes, Gallium Coordination The reaction of /V,/V-di('butyl)-ethane1,2-diamine with NaH followed by anhydrous GaCl3 (molar ratios 1:2 :1) gives mainly an insoluble bis(diamido)gallium chloride together with a low yield (28%) of a soluble monocyclic dichlorogallium-[2-('butylamino)...

cazro3 nanoceramics were successfully synthesized at 700 c using the molten salt method, and the effects of processing parameters, such as temperature, holding time, and amount of salt on the crystallization of cazro3 were investigated. cacl2, na2co3, and nano-zro2 were used as starting materials. on heating, cacl2–nacl molten eutectic salt provided a liquid medium for the reaction of caco3 an...

Polyethylene glycol has been shown to bind to the molten globule intermediate on the bovine carbonic anhydrase B folding pathway. The mechanism of this interaction has been extensively probed. Polyethylene glycol (PEG) binds weakly to the molten globule first intermediate as measured by hydrophobic interaction chromatography, but PEG does not bind to either the native state or the second interm...

the solvent extraction of gallium from a concentrated jajarm bayer process liquor containing 164.90 g/l of na2o, 86.70 g/l of al2o3 and 106.02 ppm of gallium was investigated using 10 vol.% kelex100, a 7-alkyl substituted-8 hydroxyquinoline as an extractant, 10 vol.% etanol as a modifier and kerosene as a diluent. at (vo :va = 1.0:1.0) organic to aqueous phase ratio and at room temperature, 93....

Gallium maltolate, tris(3-hydroxy-2-methyl-4H-pyran-4-onato)gallium (GaM), is an orally active gallium compound for therapeutic use. It is moderately soluble in water (10.7 +/- 0.9 mg/mL at 25 composite functionC) with an octanol partition coefficient of 0.41+/-0.08. The molecule is electrically neutral in aqueous solution at neutral pH; a dilute aqueous solution (2.5 x10-(-5) M) showed little ...