Momordica charantia is a well known medicinal plant used in the traditional medicinal system for the treatment of various diseases including diabetes mellitus. Recently, a novel protein termed as ADMc1 from the seed extract of M. charantia has been identified and isolated showing significant antihyperglycemic activity in type 1 diabetic rats in which diabetes was induced. However, the structure...

Jarab (Scabies) is an itchy dermatosis caused by human mite Sarcotes scabiei. It usually involves inter digital spaces of hands and the flexor surface of the wrists. In severe infection, the dorsal surface of the elbows, anterior axillary folds, female breasts, periumblical area, genital area and buttocks are involved. Night itching in particular and secondary infection with postulation and lic...

Breast cancer has a significant morbidity and death rate worldwide, thus various therapeutic strategies, including the phytopharmaca approach, must be researched further. Bitter melon (Momordica charantia) extract is predicted to have anticancer properties due its influence on Caspase-9 BcL2 proteins, which will shown in this vitro investigation utilizing MCF-7 cell culture. This study was an l...

Alcoholic extract of whole fruit of Momordica charantia was prepared. Adult healthy albino rats were divided into four groups and received a dose of 6 mg/l00 gm. body weight of alloxan monohydrate. Animals of group I served as diabetic control group. The animals of II, III, and IV groups received 25 mg, 50 mg and 75 mg doses of the extract respectively for different durations. 75 mg dose showed...

The aim of this study was to determine the effect of various doses of aqueous leaf extract of Momordica charantia on fertility hormones of adult male Wistar rats. Twenty health male albino rats were randomly assigned equally to four groups: low dose (LD), medium dose (MD) and high dose (HD) groups, treated with extracts of M. charantia at 12.5g, 25.0g and 50.0g respectively for thirty days. The...

An evaluation of the rheological properties and the effects of Momordica. charantia L. (M. charantia) nanoparticles and polyethylene glycol (PEG) microspheres adsorbed with M. charantia nanoparticles on the blood of hyperglycemic patients is presented. Blood samples were collected according to glycemic status: normoglycemic (N = 56) and hyperglycemic (N = 26). General and hematological characte...

Bitter Melon (Momordica charantia) is a widely used traditional remedy for hyperglycemia. While the medicinal properties of this plant have been studied extensively using in vitro and animal models, the clinical efficacy and safety in humans is largely unknown. This review discusses the benefits and limitations of bitter melon supplementation in the context of epidemic levels of insulin resista...

Background: There is yet a dearth of literature on the antifertility effect of Momordica charantia on the male reproductive system. The aim of this study was to determine the effect of graded oral doses of methanolic seed extract of Momordica charantia on the histology of prostate gland and seminiferous tubules of rats. Methods: Forty male Sprague-Dawley rats, weighing 176±7 g were assi...