Andrew K.S. Ho, Raymond C.A. Chen and J. Michael Morrison* Peoria School of Medicine, University of Illinois, Peoria, Illinois, and National Institute on Drug Abuse, Rockville, Maryland. * This work was supported by a contract from NIDA ADM-45-74220. The authors wish to thank Drs. Monique Braude, Lou Harris, Mary Jean Kreek, Elliot Vessel and Charles Schuster for valuable suggestions, and encou...

Vitamin and mineral deficiencies may perpetuate fibromyalgia syndrome (FMS) and chronic myofascial syndrome symptoms. Vitamin D supports healthy bone renewal, promotes normal cell growth and is a key factor in the maintenance of a healthy immune system. Moreover, low blood levels of Vitamin D are associated with pain and muscle weakness. Indeed new research released by the American Society of A...

The anhedonia-like behaviors following about 1-week withdrawal from morphine were examined in the present study. Male rats were pretreated with either a binge-like morphine paradigm or daily saline injection for 5 days. Three types of natural reward were used, food reward (2.5, 4, 15, 30, 40, and 60% sucrose solutions), social reward (male rat) and sexual reward (estrous female rat). For each t...

OBJECTIVE We aimed to assess the positive percentages of urine morphine tests and correlates among methadone maintenance treatment (MMT) clients with HIV/AIDS in Guangdong, China. SETTING Fourteen MMT clinics located in nine cities of Guangdong were chosen as study sites. PARTICIPANTS In this study, we reviewed 293 clients with opioid dependence, who were HIV seropositive, 18 years or older...

Abstract Background: Socio-behavioral consulting centers offer methadone maintenance therapy which is a very useful method for drug dependents. These centers offer a wide range of services like education, consulting, prevention, care taking of patients and treatment for high risk groups such as AIDS-infected patients. Methadone maintenance therapy (MMT) is helpful in harm minimization...

BACKGROUND Although remifentanil provides profound analgesia during operation, postoperative occurrence of hyperalgesia and tolerance after remifentanil administration could be a challenge to the postoperative pain control. In this investigation, we sought to determine the effect of maintenance with propofol or sevoflurane on postoperative analgesia after remifentanil-based anaesthesia. METHO...

conclusions analysis of codeine to morphine metabolism rate is needed when we are using morphine/codeine ratio to rule out abuse of narcotics. wada should consider analysis for the cyp2d6 alleles (main metabolizer of codeine) in case of including morphine/codeine ratio in future prohibited list. the possibility of ultra-rapid cyp2d6 cannot be ruled out in certain results of morphine/codeine nea...

Background: In maintenance therapy for opioid addiction, to reduce the risk of buprenorphine (BUP) abuse, the combination of BUP and naloxone (NX) has been developed and is commercially available as suboxone (BUP/NX). This study was designed to compare addiction relapse frequency in patients receiving BUP and BUP/NX as maintenance therapy. Methods: In this double-blind clinical trial with cross...

Telaprevir (TVR) effects on P-glycloprotein and cytochrome P450 (CYP) may significantly elevate serum levels of morphine and methadone. Recent literature points to major interactions when combining TVR with warfarin or rifampin. Opioid interactions are especially dangerous in hepatitis C patients, as coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) occurs in 50-90...