Shortly after implantation the embryonic lineage transforms from a coherent ball of cells into polarized cup shaped epithelium. Recently we elucidated a previously unknown apoptosis-independent morphogenic event that reorganizes the pluripotent lineage. Polarization cues from the surrounding basement membrane rearrange the epiblast into a polarized rosette-like structure, where subsequently a c...

Bone morphogenic protein (BMP) provides excellent enhancement of fusion in many spinal surgeries. BMP should be a cautionary tale about the use of industry-sponsored research, perceived conflicts of interest, and holding the field of spinal surgery to the highest academic scrutiny and ethical standards. In the case of BMP, not having a transparent base of literature as it was approved led to de...

In this paper, we derive a four-dimensional ordinary differential equation (ODE) model representing the main interactions between Sox9, Sox10, Olig2 and several miRNAs, which drive process of (olygodendrocyte) differentiation. We utilize Lyapunov–Andronov theory to analyze its dynamical properties. Our results indicated that strength external signaling (morphogenic gradients shh bmp), transcrip...

whooping cough (pertussis) is a highly contagious disease of the human respiratory tract, which is caused by bordetella pertussis. reemerge of pertussis in some highly immunized populations and divergency in gene order among several b. pertussis strains promoted this research to study the change of pertussis toxin (pt) and lipopolysacharide levels in response to the different environments. this...

In this paper, a 7-level Diode Clamped Multilevel Inverter (DCMLI) is simulated with three different carrier PWM techniques. Here, Carrier based Sinusoidal Pulse Width Modulation (SPWM), Third Harmonic Injected Pulse Width Modulation (THIPWM) and Modified Carrier-Based Space Vector Pulse Width Modulation (SVPWM) are used as modulation strategies. These modulation strategies include Phase Dispos...

In the present issue of Circulation, Chang et al1 report novel shear stress–sensitive paracrine mechanisms that regulate the activity of bone morphogenetic proteins (BMPs) in the vascular wall. BMP2 and BMP4 are structurally related members of the transforming growth factorsuperfamily. Recent studies demonstrated that vascular endothelial and smooth muscle cells are a significant source of BMPs...