ARTICLES DISCUSSED: Bui, M., Li, Raban, R. R., Liu, N., Akbari, O. S. Embryo microinjection techniques for efficient site-specific mutagenesis in Culex quinquefasciatus. Journal of Visualized Experiments. (159), e61375 (2020). Carballar-Lejarazú, Pham, T. B., Bottino-Rojas, V., Adolfi, A., James, A. Small-Cage laboratory trials genetically-engineered anopheline mosquitoes. (171), e62588 (2021a)...

Anopheles stephensi is a principal vector of urban malaria on the Indian subcontinent and an emerging model for molecular and genetic studies of mosquito biology. To enhance our understanding of female mosquito reproduction, and to develop new tools for basic research and for genetic strategies to control mosquito-borne infectious diseases, we identified 79 genes that displayed previtellogenic ...

Vector-borne diseases constitute an enormous burden on public health across the world. However, despite the importance of interactions between infectious pathogens and their respective vector for disease transmission, the biology of the pathogen in the insect is often less well understood than the forms that cause human infections. Even with the global impact of Plasmodium parasites, the causat...

Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, 69 Pasteur St, PO Box 13164, Tehran, Iran Department of Applied Mathematics, Faculty of Mathematical Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, PO Box 14115-134, Tehran, Iran Faculty of New Sciences and Technologies, University of Tehran, North Kar...

Fereshteh Alsahebfosoul1,6*, Rasoul Salehi2, Masoud Etemadifar3,5, Ahmad Zavaran Hosseini4, Mohammad Kazemi2, Mehrdad Farokhi5,6, and Mohadaseh Behjati5 1Immunology Department, Faculty of medicine, Isfahan University of medical sciences, Isfahan, Iran 2Molecular biology and genetics Department, Faculty of medicine, Isfahan University of medical sciences, Isfahan, Iran 3Neurology Department, Fac...

1 Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran, 2 Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran, 3 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran, 4 Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran...

The holobiont concept was first developed for coral ecosystems but has been extended to multiple organisms, including plants and other animals. Studies on insect-associated microbial communities have produced strong evidence that symbiotic bacteria play a major role in host biology. However, the understanding of these symbiotic relationships has mainly been limited to phytophagous insects, whil...

It has recently been proposed that mosquito vectors of human diseases, particularly malaria, may be controlled by spraying with fungal biopesticides that increase the rate of adult mortality. Though fungal pathogens do not cause instantaneous mortality, they can kill mosquitoes before they are old enough to transmit disease. A model is developed (i) to explore the potential for fungal entomopat...

The microbiota of Anopheles mosquitoes interferes with mosquito infection by Plasmodium and influences mosquito fitness, therefore affecting vectorial capacity. This natural barrier to malaria transmission has been regarded with growing interest in the last 20 years, as it may be a source of new transmission-blocking strategies. The last decade has seen tremendous progress in the functional cha...