T he magnetic resonance (MR) phenomenon was first described in 1946 2 but it was not until 1981 that the first transverse image through the human head was reported. In the last 20 years, MR technology has revolutionised medical and scientific neuroimaging, providing the richest source of information about the living brain available from any imaging technology and without the use of ionising rad...

PURPOSE To compare the MR imaging and MR angiographic changes with in vivo proton MR spectroscopic findings and to determine the spectral differences between edema and ischemia in patients with eclampsia. METHODS Spin-echo MR imaging, MR angiography, and single-voxel proton MR spectroscopy were performed in 10 patients with eclampsia. MR studies were obtained within 3 to 5 days of diagnosis a...

A recent report of detection of neural progenitor cells (NPCs) in living human brain by using in vivo proton MR spectroscopy ((1)H-MR spectroscopy) has sparked great excitement in the field of biomedicine because of its potential influence and utility in clinical neuroscience research. On the other hand, the method used and the findings described in the report also caused heated debate and cont...

Gülin Öz, PhD Jeffry R. Alger, MPhil, PhD Peter B. Barker, MPhil Robert Bartha, PhD Alberto Bizzi, MD Chris Boesch, MD, PhD Patrick J. Bolan, PhD Kevin M. Brindle, DPhil, Cristina Cudalbu, PhD Alp Dinçer, MD Ulrike Dydak, PhD Uzay E. Emir, PhD Jens Frahm, PhD Ramón Gilberto González, MD, PhD Stephan Gruber, PhD Rolf Gruetter, PhD Rakesh K. Gupta, MD Arend Heerschap, PhD Anke Henning, PhD Hoby P...

BACKGROUND AND PURPOSE The cause of developmental delay frequently is unknown, and clinicians and families can be frustrated by the lack of neuroimaging correlation especially when considering therapeutic options and long-term prognosis. We sought to determine if proton MR spectroscopy can depict abnormalities in patients with developmental delay who have structurally normal brain MR images. ...

PURPOSE To determine the potential of proton MR spectroscopy to monitor patients with childhood-onset cerebral adrenoleukodystrophy (COCALD). METHODS Single-voxel MR spectroscopy was performed in 16 children with COCALD (24 examinations) who had had no treatment and in 7 children (13 examinations) who had had bone marrow transplantation. RESULTS In the untreated children with clinically act...

BACKGROUND AND PURPOSE Differential diagnosis between malignant tumors and chronic infections in the masticator space remains challenging. The purpose of the study was to categorize various changes of both lesions by using single-voxel 1H-MR spectroscopy. MATERIALS AND METHODS Twenty-four masticator space lesions, 7 chronic infections, and 17 malignant tumors were assessed with 1H-MR spectros...

Alpers-Huttenlocher syndrome, considered a mitochondrial disease, combines encephalopathy and liver failure. An 11-year-old boy with Alpers-Huttenlocher syndrome underwent conventional MR imaging, diffusion-weighted imaging, and proton MR spectroscopy. Diffusion-weighted imaging showed cytotoxic edema interpreted as acute-phase encephalopathy. MR spectroscopy revealed a lactate peak in the cort...

We report a case of intracranial foreign body granuloma that showed features of a high grade tumor on magnetic resonance (MR) imaging. However, the relative cerebral blood volume was not increased in the enhancing mass on perfusion MRI and the choline/creatine ratio only slightly increased on MR spectroscopy. The results suggest that the lesion is benign in nature. Perfusion MRI and MR spectros...