BACKGROUND The aim of this study was to systematically assess the efficacy and safety of mineralocorticoid receptor antagonists (MRAs) for patients with heart failure (HF) and diabetes mellitus (DM). METHODS We conducted a comprehensive search for controlled studies that evaluated the efficacy and safety of MRAs in patients with DM and HF. Medline, Embase and Cochrane databases were searched....

In this paper, the classical Direct Torque Control (DTC) of Induction Motor (IM) using an open loop pure integration suffers from the well-known problems of integration especially in the low speed operation range is detailed. To tackle this problem, the IM variables and parameters estimation is performed using a recursive non-linear observer known as EKF. This observer is used to estimate the s...

Here we show that male, but not female mice lacking expression of the GTPase M-Ras developed urinary retention with distention of the bladder that exacerbated with age but occurred in the absence of obvious anatomical outlet obstruction. There were changes in detrusor morphology in Mras-/- males: Smooth muscle tissue, which exhibited a compact organization in WT mice, appeared disorganized and ...

In this paper we construct a family of divergence-free multiwavelets. The construction follows Lemari e's procedure. In the process we nd multiresolution analyses (MRA) related by diierentiation and integration to a family of biorthogonal MRAs constructed by Hardin and Marasovich. The multiscaling and multiwavelets constructed have symmetries and support properties which allow us to obtain bior...

In this paper a novel method is proposed for construction of an exponential observer for nonlinear system. The presented method is based on direct solution of dynamic error without any linearzing of nonlinear terms. Necessary and sufficient conditions for construction of direct observer are presented. Stability of the observer is checked using Lyapunov theorem. Also the ability of this observer...

The prognosis of patients with Borrmann type IV gastric cancer (Type IV) is extremely poor. Thus, there is an urgent need to elucidate the molecular mechanisms underlying the oncogenesis of Type IV and to identify new therapeutic targets. Although previous studies using whole-exome and whole-genome sequencing have elucidated genomic alterations in gastric cancer, none has focused on comprehensi...

This paper presents a different technique for the online stator resistance estimation using particle swarm optimization (PSO) based algorithm rotor flux oriented control schemes of induction motor drives without speed sensor. First, conventional proportional-integral controller-based is used sensorless scheme with two model reference adaptive system (MRAS) concepts. Finally, novel method on PSO...

non-fragile observer design is the main problem of this paper. using continuous frequency distribution, the stability conditions based on integer order lyapunov theorem are derived for lipschitz class of nonlinear fractional order systems. the proposed observer is stable beside the existence of both gain perturbation and input disturbance. for the first time, in this paper a systematic method i...

Activation of the mineralocorticoid receptor (MR) plays important roles in both physiological and pathological events. Blockade of MR signaling with MR antagonists (MRAs) has been used clinically to treat kidney and cardiac disease associated with hypertension and other chronic diseases, resulting in suppression of fibrosis in these organs. However, the current use of steroidal MRAs has been li...