BACKGROUND Methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia is a morbid infection with mortality benefit from receipt of parenteral β-lactam therapy. A substantial portion of MSSA bacteremia patients report penicillin allergy, but infrequently have true allergy. OBJECTIVE To determine the frequency and predictors of optimal and adequate therapy in patients with MSSA bacteremia. ...

BACKGROUND Most cases of reduced vancomycin susceptibility in Staphylococcus aureus reported in the literature have been in methicillin-resistant strains. We report the development of reduced vancomycin susceptibility in a series of clonally related, methicillin-susceptible S. aureus (MSSA) clinical isolates. This isogenic series permitted us to determine whether the evolution of reduced vancom...

The present study aims at bacteriophage typing of methicillin sensitive Staphylococcus aureus (MSSA) strains recovered from patients with different clinical conditions at Indira Gandhi Medical College, Shimla Himachal Pradesh. We have previously reported the emergence of such resistance among 66% S. aureus strains of Himachal Pradesh. Of these 42 MSSA strains were submitted at National Centre f...

Production of icaADBC-encoded polysaccharide intercellular adhesin, or poly-N-acetylglucosamine (PIA/PNAG), represents an important biofilm mechanism in staphylococci. We previously described a glucose-induced, ica-independent biofilm mechanism in four methicillin-resistant Staphylococcus aureus (MRSA) isolates. Here, biofilm regulation by NaCl and glucose was characterized in 114 MRSA and 98 m...

OBJECTIVE To compare a retrospective cohort of nonhospitalized children with methicillin-resistant Staphylococcus aureus (MRSA) otorrhea with those with methicillin-sensitive S aureus (MSSA) otorrhea to determine the risk factors predisposing to MRSA otorrhea and the treatments used. DESIGN Retrospective case-controlled series. SETTING Tertiary pediatric care facility. PATIENTS Seventeen ...

Background. MSSA bacteremia is a common cause of community-acquired and hospital-acquired infections with significant morbidity and mortality. Ceftriaxone is a third generation cephalosporin with activity against gram positive and gram negative aerobic bacteria including MSSA. It is well tolerated and offers significant cost reduction with its once daily dosing in the outpatient setting. Althou...

TO THE EDITOR—Methicillin-susceptible Staphylococcus aureus (MSSA) prosthetic joint infection (PJI) is difficult to treat even with surgical debridement and antimicrobial therapy. The antimicrobial agents of choice for MSSA are typically oxacillin, nafcillin, and cefazolin [1]. The use of ceftriaxone for MSSA PJI is controversial, as mentioned in the recently published Infectious Diseases Socie...

Prevalence, drug resistance and genetic characteristics were analysed for a total of 128 clinical isolates of staphylococci obtained from a tertiary hospital in Myanmar. The dominant species were S. aureus (39%) and S. haemolyticus (35%), followed by S. epidermidis (6%) and S. saprophyticus (5%). The majority of S. haemolyticus isolates (71.1%) harboured mecA, showing high resistance rates to a...

BACKGROUND The mecA gene, encoding methicillin resistance in staphylococci, is located on a mobile genetic element called Staphylococcal Cassette Chromosome mec (SCCmec). Horizontal, interspecies transfer of this element could be an important factor in the dissemination of methicillin-resistant S. aureus (MRSA). Previously, we reported the isolation of a closely related methicillin-susceptible ...

OBJECTIVES To compare characteristics of methicillin resistant Staphylococcus aureus (MRSA) and methicillin susceptible S. aureus (MSSA) bacteraemia detected on admission to a UK hospital and to determine whether these organisms are community-acquired. METHODS Consecutive cases of MRSA bacteraemia admitted to general medicine between 2003 and 2006 were identified and compared to MSSA age-matc...