PURPOSE Mucosa-associated lymphoid tissue (MALT) specifically protects mucosal surfaces. In a previous study of the human conjunctiva, evidence was also found for the presence of MALT in the lacrimal sac. The present study, therefore, aims to investigate its morphology and topographical distribution in the human lacrimal drainage system. METHODS Lacrimal drainage systems (n = 51) obtained fro...

Low-grade MALT-type lymphomas are malignancies of mucosal marginal-zone B cells and preceded by reactive inflammatory lymphoid tissue. Experimental observations suggest that antigen and CD40 Ligand act during cognate T/B cell interaction and are crucial for germinal center B-cell maturation generating marginal-zone B cells. To investigate the mechanisms underlying the development of extranodal ...

Approximately 360,000 new cases of non-Hodgkin’s lymphoma were diagnosed worldwide in 2014. Of these, approximately 7% were diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric extranodal marginal zone B-cell MALT lymphoma accounts for 1%–7% of malignant gastric tumors and 60%–75% of gastrointestinal MALT lymphomas. Gastric MALT lymphoma shows various endoscopic findings. T...

Several therapies to improve the management of lymphoma are currently being investigated, necessitating development new biomarkers. However, this requires high-quality and clinically annotated biological material. Therefore, we established a biobank including all available material (tissue specimens matched resources) along with associated clinical data for patients diagnosed, according WHO cla...

Localized (primary) pulmonary amyloidosis associated with pulmonary low-grade B cell lymphoma is rarely occurred. Here we report an unusual case of nodular pulmonary amyloidosis and obvious ossification due to primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma with extensive plasmacytic differentiation in a 59-year-old man; moreover, two bronchial lymph nodes were involved hist...

RATIONALE Mucosa-associated lymphoid tissue (MALT) lymphoma is a low grade malignant B cell lymphoma which occurs mainly in the organs having mucosal layer. Though gastrointestinal tract is the most commonly involved extranodal site, primary esophageal MALT lymphoma is very rare with less than 20 cases reported in literature. PATIENT CONCERNS A 75-year-old man was referred to our hospital for...

the gastrointestinal tract is the most frequently involved extranodal location for malt* lymphomas, but malt lymphomas of the large intestine are rarely observed. a treatment for colorectal malt lymphoma has not yet been established. in colonic malt lymphomas, the literature suggests that surgical resection of localized lesion may be the best choice. in the present case, combination of multi-ag...

We describe an unusual case of adult T-cell leukemia/lymphoma (ATL)appearing in a 44-year-old female without leukemic change and systemic lymphadenopathy,which originated from the gastric wall and partially involved the paragastric lymph nodes. No other intraabdominal or intrathoracic organs, such as the liver,spleen,kidneys,adrenals,lungs,or bone marrow,were involved at the time of surgery. Th...

BACKGROUND/AIM Lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the stomach usually occurs as a consequence of Helicobacter pylori (H. pylori) infection. The aim of this study was to investigate the long-term effect of treatment of low-grade gastric MALT lymphoma with the H. pylori eradication method. METHODS In the period 2002-2012 in 20 patients with dyspepsia, mean age 55.1...