The emergence of multidrug-resistant (MDR) pathogens within biofilms in the cystic fibrosis lung results increased morbidity. An inhalation therapy derived from alginate, OligoG CF-5/20, is currently clinical trials for patients.

Penggunaan berbagai macam antibiotik menyebabkan kejadian resistensi cepat berkembang. Acinetobacter baumannii dan Pseudomonas aeruginosa adalah bakteri multidrug resisten yang sering dikaitkan dengan terjadinya kegagalan terapi. Berbagai negara menggunakan herbal sebagai pengobatan alternatif penyakit infeksi. Studi sebelumnya menunjukkan aktivitas antibakteri dimiliki Hibiscus sabdariffa (ros...


 Introduction : Multidrug-resistant TB (MDR TB) is a type of that resistant to at least two the first-line antimicrobials, isoniazid (INH) and rifampin (RMP), with or without resistance other antimicrobials. The factors causing MDR-TB were age, gender, education level, income, occupation, medication adherence, knowledge, attitudes, stigma, smoking habits, role PMO, side effects treatment....

Advances in chemotherapy have failed to improve the long-term survival rate of small cell lung cancer (SCLC) patients due to multidrug resistance (MDR). The mechanisms of MDR are complex involving multiple genes and a variety of mechanisms. MicroRNAs (miRNAs) are non-coding RNAs theoretically involved in gene regulation. The aim of the present study was to explore the role of miRNAs in SCLC occ...

Effective therapy of high-risk leukemia with established cytotoxic drugs may be limited by poor antitumor efficacy, systemic toxicity, and the induction of drug resistance. Here, we provide the first evidence that hydrolytically activated prodrugs may overcome these problems. For this purpose, VP16 was functionally blocked by hydrolytically cleavable carbonate linkers with unique characteristic...

Abstract Introduction Escherichia coli is an opportunistic bacteria that can grow easily, produce toxins, and resist antibiotics. The phenomenon of E. developing multidrug resistance currently the subject extensive research. objective this study was to molecularly identify bla TEM CTX-M genes in multidrug-resistant found milk samples from dairy cattle farms Tulungagung, Indonesia. Material Meth...

BACKGROUND Despite evidence that altered membrane porins may impair microbial drug uptake thereby potentially compounding efflux pump-mediated multidrug resistance, few studies have evaluated gene transcription to identify multidrug-resistance-associated porins and other potential drug targets. METHODS Genes that encode six membrane porins (fadL, lamB, ompC, ompF, ompW and yiaT) and two membr...

BACKGROUND Multidrug-resistant tuberculosis (MDR-TB) is posing a great threat to global TB control. The burden in Zambia is not well defined because routine surveillance data are scarce. We reviewed national MDR-TB data for the last decade to inform future public health policy with respect to MDR-TB in Zambia. METHOD Retrospective review of national surveillance of MDR-TB data, TB programme a...

Corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. However, little is known about its virulence factors that may contribute to healthcare-associated infections (HAIs). We investigated the biofilm production on abiotic surfaces of multidrug-resistant (MDR) and multidrug-susceptible (MDS) strains of C. striatum of pulsed-field gel electrophoresis ...

In this study, our objectives was to analyze the molecular characteristics of mutation at embB codon306 in Mycobacterium tuberculosis in Qingdao by pyrosequencing technology, and to assess the value of embB codon306 used as a molecular marker to diagnose multidrug resistant (MDR) TB strains. Pyrosequencing was used to detect mutations at embB codon306 among M. tuberculosis isolates from tubercu...