http://ccn.aacnjournals.org Kevin J. O’Connor is the director of organ donation services for the New England Organ Bank in Newton, Mass, and codirector of the Organ Transplantation Breakthrough Collaborative. Kenneth E. Wood is a professor of medicine and anesthesiology, Department of Medicine, and director of Critical Care Medicine/Respiratory Care and the Trauma and Life Support Center at the...

Over the past 15 years, the shortage of organs for transplantation has worsened. This has forced clinicians to review alternative approaches to organ procurement. These new approaches, however, may have serious implications both for patients and for society as a whole. Ever since the first cadaver organs were used for transplantation, organ procurement has relied on the altruism and goodwill of...

Following the discovery of endotoxins by Richard Pfeiffer, such bacterial product was associated to many severe disorders produced by an overwhelming inflammatory response and often resulting in endotoxic shock and multiple organ failure. However, recent clinical and basic sciences investigations claimed some beneficial roles of typical as well as atypical endotoxins. The aim of this paper is t...

INTRODUCTION ............................................................................................... 609 I. BACKGROUND ..................................................................................... 611 A. Organ Transplantation in the United States ................................ 611 B. The HOPE Act ............................................................................. 615...

Growth regulator X1 promotes growth, is produced locally (purple area) and has limited mobility. This causes a spatial growth gradient (faster growth in darker green). Growth will arrest in a wave from right to left as X1 levels decrease. Growth regulator X2 promotes growth, is produced locally (orange area) and is sufficiently mobile to affect growth in the same way across the tissue. If only ...