Recent studies have revealed widespread demyelination in the cortex of patients with chronic multiple sclerosis. In contrast to white matter lesions, cortical multiple sclerosis lesions are accompanied by only minor inflammation. Research into the pathogenesis of cortical lesion formation has been hampered by the fact that the conventional rodent model of multiple sclerosis, experimental autoim...

introduction: several treatment options have been introduced for removal of gingival hyperplasic lesions, but using diode lasers have many advantages such as less bleeding, time saving, better shaping, improved healing and less complication for the patients. case: a 15-year-old girl with multiple fibroma-like lesions in the oral cavity, who had a medical history of tuberous sclerosis, was selec...

Brain MRI and multimodal evoked potentials (EPs) were obtained for 13 patients with benign multiple sclerosis and 13 patients with secondary progressive multiple sclerosis, matched for age and duration of the disease, to investigate the nature of the disability in multiple sclerosis. Patients with secondary progressive multiple sclerosis had significantly greater lesion loads for five of seven ...

Some recent studies suggest that in progressive multiple sclerosis, neurodegeneration may occur independently from inflammation. The aim of our study was to analyse the interdependence of inflammation, neurodegeneration and disease progression in various multiple sclerosis stages in relation to lesional activity and clinical course, with a particular focus on progressive multiple sclerosis. The...

To study the clinico-radiological paradox in multiple sclerosis (MS) relapse by analyzing number and location of gadolinium-enhanced (Gd+) lesions on brain MRI before methylprednisolone (MP) treatment. We analyzed from 90 relapsed MS patients two Phase IV multicenter double-blind randomized clinical trials that showed noninferiority different routes doses MP administration. A 1.5- or 3-T was pe...