background: statins, widely used cholesterol-lowering agents, have also been demonstrated to have anti-inflammatory and immunomdulatory effects. objective: to evaluate the effects of atorvastatin in combination with interferon-β in the treatment of multiple sclerosis (ms) in a randomized controlled clinical trial. methods: multiple sclerosis patients were randomized independently, in a double b...

background: there is a known inverse association between solar radiation and the prevalence of multiple sclerosis (ms). some studies have investigated the link between vitamin d and ms. the aim of this study was to investigate the possible association between serum 25(oh) vitamin d3 concentration and the severity of disease in iranian patients with ms. methods: patients with relapsing-remitting...

Higher-order multiple-scale methods for general multiparameter mechanical systems are studied. The role played by the control and imperfection parameters in deriving the perturbative equations is highlighted. The definition of the codimension of the problem, borrowed from the bifurcation theory, is extended to general systems, excited either externally or parametrically. The concept of a reduce...

This paper exposes an idea for dual level control architecture for use in large-scale systems consisting of networks of smaller subsystems whose dynamical behavior exhibits multiple time scales. The proposed control scheme is decentralized in nature at the low level: The communication among subsystems is done indirectly through the high level control, whose design is based on a singularly pertu...

Many physical problems, particularly in chemical and biological systems, involve processes that occur over widely varying time scales. Such problems have motivated the development of new methods for treating multiple-time-scale problems in molecular dynamics (MD). Methods have been developed for determining the vibrational frequencies and normal modes of large systems in full and reduced confor...