PURPOSE Open surgical muscle biopsy (OB) and percutaneous Bergstroem needle muscle biopsy (NB) are equally accepted procedures. However, there are no data comparing intraprocedural pain for both techniques. We designed this prospective trial to test the hypothesis that the less invasive NB causes less intraprocedural pain than OB. METHODS In a two-center prospective trial, 33 patients underwe...

Duchenne muscular dystrophy is a severe and currently incurable progressive neuromuscular condition, caused by mutations in the DMD gene that result in the inability to produce dystrophin. Lack of dystrophin leads to loss of muscle fibres and a reduction in muscle mass and function. There is evidence from dystrophin-deficient mouse models that increasing levels of utrophin at the muscle fibre s...

  Muscle tissue, skeletal muscle as well as cardiac muscle, is commonly affected in mitochondrial disorders. One explanation for this observation is that muscle tissue has a high-energy demand and therefore is more sensitive to a deficiency of mitochondrial energy production than some other tissues. In mitochondrial disorders, skeletal muscle tissue may be affected primarily by defective respi...

The clinical and laboratory findings of a patient with juvenile acid maltase deficiency are presented. The patient died from respiratory muscle weakness at age 31 years. Muscle biopsy shortly prior to his death showed remarkable vacuolation affecting exclusively type I fibres and mild myopathic changes of both types of muscle fibres, while the muscle biopsy at age 26 years had shown no evidence...

Muscle specimens obtained at necropsy from four cases of neuronal ceroid-lipofuscinosis (NCL), three of the juvenile and one of the late infantile type, and a muscle biopsy from a fifth patient with the juvenile type of NCL, all showed curvilinear bodies typical of NCL within the muscle fibres. The pigments were autofluorescent. It appears that skeletal muscle is a reliable tissue source for th...

The aim of this study was to define normal ranges of histological features in pediatric muscle in comparison with muscle demonstrating inflammatory changes. Sixteen pediatric muscle biopsy samples, considered normal by standard histology, were analyzed for the presence of inflammatory cells, and the expression of neonatal myosin and major histocompatibility complex (MHC) Class 1. Normal finding...

Citation: Chaudhury A (2016) Response: “Commentary: A Hypothesis for Examining Skeletal Muscle Biopsy-Derived Sarcolemmal nNOSμ as Surrogate for Enteric nNOSα Function”. nNOS muscle may be Evidentiary for Enteric NO-Transmission Despite nNOSμ/α Differences. Front. Med. 3:4. doi: 10.3389/fmed.2016.00004 response: “Commentary: a Hypothesis for examining Skeletal muscle Biopsy-Derived Sarcolemmal ...

Breast cancer rarely metastasizes to skeletal muscle. Moreover, muscle is a rare site of metastasis for any type cancer. In this study, we report an unexpected finding enlarged mass in the gluteus maximus asymptomatic patient with distant history breast The was observed during computed tomography evaluation preparation non-oncologic procedure. Biopsy and pathological investigation confirmed met...

Muscle biopsy image morphometric analysis provides valuable diagnostic information to expert clinicians. Subsequently, there is an indispensable need to support muscle fiber morphometry with computer-aided automated systems that require no user interaction. The first step towards producing such a system is the automated border detection of muscle fibers. The objective of this work is to investi...

muscle tissue, skeletal muscle as well as cardiac muscle, is commonly affected in mitochondrial disorders. one explanation for this observation is that muscle tissue has a high-energy demand and therefore is more sensitive to a deficiency of mitochondrial energy production than some other tissues. in mitochondrial disorders, skeletal muscle tissue may be affected primarily by defective respirat...