INTRODUCTION In this study we evaluated the relationships among the behavioral changes after muscle injury, histological changes, changes in inflammatory cytokines in the injured muscle, and changes in the sensory nervous system innervating the muscle in rats. METHODS We established a model of muscle injury in rats using a dropped weight. Behavior was assessed using the CatWalk system. Subseq...

Skeletal muscle injury is often assessed by clinical findings (history, pain, tenderness, strength loss), by imaging, or by invasive techniques. The purpose of this work was to determine if in vivo proton magnetic resonance spectroscopy ((1)H MRS) could reveal metabolic changes in murine skeletal muscle after contraction-induced injury. We compared findings in the tibialis anterior muscle from ...

Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle-specific microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here, we show that mi...

background: vitamin d, especially its most active metabolite 1,25-dihydroxyvitamin d₃(vit d) is essential in regulating a wide variety of biologic processes, such as regulating mesangial cell activation. the objective of this study was to assess the histopathological changes of effectiveness of vit d as a protective agent against radiation induced lung injury. materials and methods: eighteen wi...

Background: Knee extension torque control decreases after anterior cruciate ligament (ACL) rupture. There is a controversy in neuromuscular control changes on the uninvolved side. We intended to evaluate the steadiness and accuracy of quadriceps muscle control in the healthy and deficient sides of people with acute ACL rupture.    Methods: In this cross-sectional study, thirteen men with ACL r...

BACKGROUND Although bupivacaine has been used to study muscle degeneration and regeneration, the potential enhancement of muscle injury by exercise has not been well examined. The purpose of this study was to determine whether low-intensity treadmill exercise enhances fast recovery from bupivacaine-induced muscle injury and to examine concomitant changes in heat-shock protein 70 (HSP70) express...

The effect that compressed air massage (CAM) has on skeletal muscle has been ascertained by the morphological and morphometric evaluation of healthy vervet monkey and rabbit skeletal muscle. How CAM may influence the process of healing following a contusion injury is not known. To determine how CAM or other physiotherapeutic modalities may influence healing, it is necessary to create a minor in...

The purpose of the present investigation was to examine the effect of exercise-induced muscle injury on hemodynamic responses during exercise. Ten subjects performed unilateral isometric knee extensions (IKE) at 30% of preinjury maximum voluntary contraction to fatigue and for 3 min before and 48 h after muscle injury. Muscle injury was elicited by performing 8 sets of 10 repetitions of eccentr...

Neurorehabilitation of patients with spinal cord injury and severe muscle spasticity have always been one the most challenging tasks for neurologists. Muscle significantly impairs patients’ quality life is often resistant to pharmacotherapy. Over last 10 years, intrathecal baclofen therapy has become effective treatment in Russia. In this study, we tried systematize data on complicated by evalu...

The primary aim was to assess impact of early knee status on self-reported function at 3 and 12 months quadriceps strength after non-surgically treated ACL injury. secondary describe the recovery muscle during first year Prospective cohort study. 70 patients (42 males; mean age 27 ± 7 years) with acute Knee symptoms, sporting activities were assessed International Documentation Committee Subjec...