To evaluate the agreement between QuantiFERON-TB Gold In-Tube test (QFT-GIT) and tuberculin skin test (TST) for the screening of latent tuberculosis infection (LTBI) in recent immigrants to Italy, 279 subjects were submitted to concomitant TST and QFT-GIT. The agreement was analyzed using k statistics. A total of 72/279 (25.8%) individuals were TST positive, while 107/279 (38.3%) were QFT-GIT p...

The COMPTEL experiment aboard the Compton Gamma-Ray Observatory (CGRO) has observed the gamma-ray blazar 3C 279 several times between April 1991 and September 1995. This paper reports on a consistent analysis of these observations using the most recent COMPTEL data analysis tools. Detections and non-detections of 3C 279 along the CGRO-mission indicate a time-variable MeVflux. Spectral variabili...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kuchar E, Czajka H, Gowin et al. Recommendations of the Polish Paediatric Society, Society Vaccinology, and Family Medicine on meningococcal vaccinations in children adults Poland. Pediatria Polska - Journal Paediatrics. 2022;97(4):279-289. doi:10.5114/polp.2022.123913. APA Kuchar, E., Czajka, H., Gowin, Nitsch-Os...

Archival IUE SWP and HST FOS spectra show the presence of a relatively strong, broad Lyman α emission line superposed onto the UV spectral continuum of the blazar 3C 279. As opposed to a factor ∼50 variation of the continuum flux during eight years, the emission line did not exhibit significant intensity changes. Simultaneous IUE SWP and LWP spectra of 3C 279 in low emission state are fitted by...

Background: Docetaxel is the first-line treatment for castration-resistant prostate cancer (CRPC). The limited survival benefit associated with the quick emergence of resistance and systemic toxicity diminishes its efficacy in high-dose monotherapy. YK-4-279 is a small molecule inhibitor of ETV1 that plays an important role in the progression of prostate cancer. The aim of this study was to eva...

Lengsin is an eye lens protein with a glutamine synthetase domain. We previously identified this protein as a lung carcinoma antigen through cDNA microarray analysis. Lengsin protein is overexpressed irrespective of the histological type of lung carcinoma, but not in normal tissues other than the lens. Therefore, to significantly extend the use of Lengsin-based T-cell immunotherapies for the tr...

Transcription factors have long been deemed 'undruggable' targets for therapeutics. Enhanced recognition of protein biochemistry as well as the need to have more targeted approaches to treat cancer has rendered transcription factors approachable for therapeutic development. Since transcription factors lack enzymatic domains, the specific targeting of these proteins has unique challenges. One ch...

Interleukin 6 plays a key role in mediating inflammatory reactions in autoimmune diseases and cancer, where it is also involved in metastasis and tissue invasion. Neutralizing antibodies against IL-6 and its receptor have been approved for therapeutic intervention or are in advanced stages of clinical development. Here we describe the crystal structures of the complexes of IL-6 with two Fabs de...