We consider a system of parallel queues where arriving service tasks are buffered, according to type. Available service resources are dynamically configured and allocated to the queues to process the tasks. At each point in time, a scheduler chooses a service configuration across the queues, in response to queue backlogs. Switching from one service configuration to another incurs a setup time, ...

Gabapentin is one of the new antiepileptic drugs (AEDs) launched recently. The advantage of new AEDs includes newer mechanism of action, broad spectrum of antiseizure effects, lesser drug interactions and fewer side effects. Gabapentin (GBP) a GABA analogue, is efficacious in several neurological and psychiatric conditions and it is conventionally used in the treatment of partial epilepsies. In...

Genome-wide association studies indicated the homeobox-containing transcription factor Engrailed-2 (En2) as a candidate gene for autism spectrum disorders (ASD). Accordingly, En2 knock-out (En2(-/-)) mice show anatomical and behavioral "ASD-like" features, including decreased sociability and learning deficits. The molecular pathways underlying these deficits in En2(-/-) mice are not known. Defi...

Nefiracetam, a pyrrolidone derivative, is a nootropic agent that has facilitated cognitive function in a wide variety of animal models of cognitive dysfunction. The purpose of this study was to investigate the efficacy of the chronic postinjury administration of nefiracetam (DM-9384) in improving cognitive performance following central fluid percussion brain injury in rats. Twenty-four hours fo...

sporadic alzheimer’s disease (sad) is a multi-factorial disease caused by genetic, epigenetic, environmental and metabolic factors. current understandings of the possible mechanisms of ad such as inflammation and oxidative stresses in the brain have led us to investigation of potential ad therapeutics. currently herbal medicines with fewer side effects comparing to other chemical medicine are i...

Prior research studying the relationship between music training (MT) and more general cognitive faculties, such as visuospatial working memory (VSWM), often fails to include tests of musical memory. This may result in causal pathways MT other variables being misrepresented, potentially explaining certain ambiguous findings literature concerning executive functions. Here we address this problem ...

Input Queued(IQ) switches have been very well studied in the recent past. The main problem in the IQ switches concerns scheduling. The main focus of the research has been the £xed length packet-known as cells-case. The scheduling decision becomes relatively easier for cells compared to the variable length packet case as scheduling needs to be done at a regular interval of £xed cell time. In rea...

Mitochondrial dysfunction is involved in aging and in neurodegenerative diseases and, therefore, pharmacological agents that alleviate mitochondrial dysfunction are expected to have neuroprotective effects. Promising in this respect is mitochondrial-targeted antioxidant plastoquinonyl-decyl-triphenylphosphonium (SkQ1). We investigated the effects of SkQ1 (250 nmol SkQ1/kg x day with food) on be...

Lead (Pb) is found to impair cognitive function. Synaptic structural plasticity is considered to be the physiological basis of synaptic functional plasticity and has been recently found to play important roles in learning and memory. To study the effect of Pb on spatial learning and memory at different developmental stages, and its relationship with alterations of synaptic structural plasticity...

Introduction: Previous studies have shown that exercise enhances cognitive and functional capacities in patients with Alzheimer's disease (AD). In this study, we investigated the effect of long-term (60 days) and shortterm (10 days) exercise on the spatial memory deficits in an animal model of AD. Methods: Fifty male rats were divided into 5 groups; 1) intact, 2) sham, 3) sham-Alzheimer 4) Alzh...