نتایج جستجو برای: myelofibrosis
تعداد نتایج: 4073 فیلتر نتایج به سال:
Background: Primary myelofibrosis is characterized by clonal expansion of hematopoietic stem cell with a non-reactive clonal proliferation of fibroblasts and bone marrow fibrosis, which occurs at an extramedullary hematopoiesis. The clinical features of Primary myelofibrosis include anemia, marked splenomegaly and constitutional symptoms. Ineffective erythropoiesis and extra-medullary hematopoi...
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the Janus kinase 2 gene (JAK2), and an additional 5 to 10% have activating mutations in the thrombopoietin receptor gene (MPL). So far, no specific molecular marker has been identified in the remaining 30 to 45% of patients. METHODS We performed whole-exome sequencing to ...
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma, characterized by high clinical and biological heterogeneity. Patients typically present with progressive lymphadenopathy, extranodal disease may also experience fever, night sweats unexplained weight loss. We report here case of a 16-year-old female osteoarticular pain, dizziness, dyspnea on exertion. Clinical examin...
Myeloproliferative Neoplasm (MPN) are a clonal disorder in hematopoietic stem cells (HSC). MPN is categorized to 8 subclasses, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocytopenia (ET), primary myelofibrosis (PMF), systematic mastositosis (SM), chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia (CNL), and unclassified myelofibrosis disorde...
A rare clinical observation of advanced myeloid sarcoma developed through blast transformation post-polycythemia vera myelofibrosis as extramedullary manifestation acute leukemia affecting larynx, laryngopharynx, trachea, soft tissues the neck, pleura, and skeletal bones is presented.
we describe a case of leishmaniasis in a 55-year-old male who presented with weakness, fever and anemia. the patient was born and lived all his life in talaghan, a non-endemic region of kala-azar and there was no history of travel to endemic reigon for leishmania. in primary diagnosis, the patient suspect has been myelofibrosis and then lymphoma and underwent chemotherapy . his general conditio...
A 59 year old man with longstanding myelofibrosis and previous splenectomy was incidently found to have a large lytic lesion in his left femur which required operative fixation. He had undergone right upper lobectomy for squamous carcinoma of the bronchus five years earlier. Histological analysis of bone reamings showed no evidence of metastatic carcinoma. Osteosclerosis is frequently noted in ...
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