The objective of this study was to examine the tumor spatial heterogeneity in myxoid-containing soft-tissue tumors (STTs) using texture analysis of diffusion-weighted imaging (DWI). A total of 40 patients with myxoid-containing STTs (23 benign and 17 malignant) were included in this study. The region of interest (ROI) was manually drawn on the apparent diffusion coefficient (ADC) map. For textu...

Epithelioid gastrointesinal tumors (GISTs) are less likely to have c-kit gene mutations (and express CD117) than spindle cell GISTs. CD117 negative/c-kit negative GISTs can have platelet-derived growth factor alpha (PDGFRα) gene mutations, overexpress PDGFRα protein and respond to imatinib mesylate. Many cases of CD117-negative/CD117weakly positive, c-kit mutation negative and PDGFRα mutation p...

Adrenocortical adenoma is a benign neoplasm derived from cells of the adrenal cortex. The myxoid variant of this tumor is extremely rare. To our knowledge, only 23 cases of myxoid adrenocortical adenoma have been reported so far and 19 of them mentioned the pseudoglandular pattern. We reported a new case of 56-year-old Chinese female patient whose left adrenal gland was shown a neoplastic lesio...

Dear Dr. Bedrossian: Although histological examination is by-and-far considered the gold standard for most soft tissue diagnoses, fine needle aspiration (FNA) is an excellent modality to determine the initial characteristics of the lesion in question. To our knowledge, there have been only two reported cases of ordinary lipoma and spindle-cell lipoma occurring at the same time in the same patie...

Myxoid liposarcomas account for more than one third of liposarcomas and about 10% of all adult soft tissue sarcomas. The tumors are characterized by specific chromosomal translocations leading to the chimeric oncogenes FUS-DDIT3 or EWS1R-DDIT3. The encoded fusion proteins act as aberrant transcription factors. Therefore, we implemented comparative expression analyses using whole-genome microarr...

Myxoid DFSP expresses apolipoprotein D and presents with a storiform pattern and characteristic subcutaneous infiltration. Diagnosis is confirmed by detection of the chromosomal translocation t(17;22). The differential diagnosis should include benign myxoid lesions with spindle-shaped cells (myxoid neurofibroma, superficial angiomyxoma, mucous cyst), malignant myxoid lesions with spindle-shaped...

Myxomas are benign tumors that generally arise from the heart, soft tissues, muscle, skin and bone (1). Herein we present a myxoma case found on the ovary. A 12-year-old girl was under follow-up for menstrual irregularities for 1 year and pelvic ultrasonography revealed bilateral para-ovarian simple semisolid lesions. Pelvic magnetic resonance imaging was performed, and a cystic lesion (65×4 cm...

Endometrial stromal tumors are reviewed with emphasis on their wide morphologic spectrum and problems in differential diagnosis, highlighting issues that have received particular attention in the recent literature. These neoplasms are divided into two major categories--endometrial stromal nodules and endometrial stromal sarcomas--a distinction made on the basis of the lack of significant infilt...

Giant cell tumor of the tendon sheath is a benign soft tissue tumor most frequent between the third and fifth decades of life. It can mimic and make differential diagnoses with several hand tumors. Definitive diagnosis and the treatment of choice are reached with complete resection and histopathological examination. Here we describe a case with clinical presentation similar to that of a myxoid ...