BACKGROUND Contrast-induced nephropathy is one of the common causes of acute renal insufficiency after cardiovascular procedures. HYPOTHESIS The objective of this paper was to analyze the published data on the usefulness of N-acetylcysteine in the prevention of contrast-induced nephropathy after these procedures. METHODS Trials were selected if they were prospective, randomized, controlled,...

CONTEXT Trichotillomania is characterized by repetitive hair pulling that causes noticeable hair loss. Data on the pharmacologic treatment of trichotillomania are limited to conflicting studies of serotonergic medications. N-acetylcysteine, an amino acid, seems to restore the extracellular glutamate concentration in the nucleus accumbens and, therefore, offers promise in the reduction of compul...

BACKGROUND Patients with acute myocardial infarction undergoing primary angioplasty are at high risk for contrast-medium-induced nephropathy because of hemodynamic instability, the need for a high volume of contrast medium, and the lack of effective prophylaxis. We investigated the antioxidant N-acetylcysteine for the prevention of contrast-medium-induced nephropathy in patients undergoing prim...

We reevaluate the treatment of mercury poisoning, incorporating recent advances in understanding toxicity and mercury:selenium interaction. This review focuses on: 1) role, limitations benefits chelation (Unithiol, succimer N-Acetylcysteine); 2) role selenium supplementation; 3) how different forms are impacted by use selenium. Unithiol produce increases urinary excretion to a lesser degree blo...

Oxidative stress may play a role in chronic obstructive pulmonary disease (COPD) exacerbations. There is heterogeneity in the literature with regard to the impact of antioxidant therapy on COPD exacerbation frequency. Clinical trials of N-acetylcysteine in COPD were identified in unrestricted searches of MEDLINE, CINAHL, International Pharmaceutical Abstracts and the Cochrane Register. Randomiz...

N-acetylcysteine (NAC), the acetylated variant of the amino acid L-cysteine, is an excellent source of sulfhydryl (SH) groups, and is converted in the body into metabolites capable of stimulating glutathione (GSH) synthesis, promoting detoxification, and acting directly as free radical scavengers. Administration of NAC has historically been as a mucolytic agent in a variety of respiratory illne...

OBJECTIVE To evaluate oral N-acetylcysteine in the prevention of contrast induced nephropathy (CIN) in patients at low to moderate risk undergoing cardiac catheterisation with ionic low osmolality contrast medium. METHODS In a multicentre double blind clinical trial 156 patients undergoing coronary angiography or percutaneous coronary intervention with serum creatinine > or = 106.08 micromol/...

We aimed to examine trichotillomania (TTM), a rarely seen disorder, and N-acetylcysteine (NAC), an agent used as a treatment option, in the light of literature in the present study. Trichotillomania is the compulsive urge to pull out one’s own hair persistently and leading to noticeable hair loss. Contrary to what is expected, it is a more frequently detected disorder characterized by compulsiv...

OBJECTIVE To examine the combined effect of hyperbaric oxygen and N-acetylcysteine, a well-studied antioxidant, on fibroblast proliferation and production of 3 specific growth factors: basic fibroblast growth factor, vascular endothelial growth factor, and transforming growth factor beta1. DESIGN In vitro study. SUBJECTS None. INTERVENTIONS Human dermal fibroblasts were propagated in seru...