The purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (SS) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. The influence of various permeation enhancers, such as dimethyl sul...

In this work attempts were made to evaluate K+-SDS and hydrocolloid polymer-SDS interactions in flocculation of megestrol acetate dispersions to enhance their stability as a part of suspension formulation. Different dispersions of micronized megestrol acetate and SDS were prepared. KCl and KH2PO4 and their corresponding sodium salts were added to the dispersions and the preparations were evalua...

BACKGROUND Urea is a natural protein degradation product widely used in keratolytic preparations due to its property to promote fibrinogen decomposition and to act as a proteolytic agent dissolving and denaturing proteins. Preparations containing 20% or 40% urea in commercial ambiphylic bases are widely used to produce keratolysis. At such high concentration urea recrystallization occurs and is...

Background: The metabolic disorder caused by high blood glucose levels and pancreatic beta-cell damage is known as diabetes mellitus. Indonesia itself the 7th country in world with number of people occupies rank 7 Apart from that, robusta coffee (Coffea canephora L) one most popular drinks globally, including Indonesia. Chlorogenic acid beans effectively reduces cell due to free radicals, minim...

Background: Diabetes Mellitus (DM) is a metabolic disease characterized by elevated blood sugar levels or chronic hyperglycemia. has been shown to have an adverse effect on male and female reproductive function its impact can be seen in the increasing prevalence of infertility. Pakkat believed used as medicine for diabetes mellitus. The chemical compounds contained pakkat consist flavonoids, al...

in recent decades, most of researchers in pharmaceutical preparations have focused increasingly on new formulations that control the site and amount of drug delivery. mucoadhesive dosage forms are available for systemic or local treatment. the mucoadhesive dosage forms are introduced in various forms such as tablets, gels, ointments, patches and polymeric films. for buccal wound and injury the ...

Frequent dosing of the potent anti-androgen, flutamide, is necessary to reach a therapeutic level for the treatment of prostatic carcinoma. Sustained delivery of the drug could reduce the adverse effects such as gastrointestinal disorders and improve patient compliance. In the present study sustained-release matrix tablets of flutamide were prepared by direct compression method using different ...

       In recent decades, most of researchers in pharmaceutical preparations have focused increasingly on new formulations that control the site and amount of drug delivery. Mucoadhesive dosage forms are available for systemic or local treatment. The mucoadhesive dosage forms are introduced in various forms such as tablets, gels, ointments, patches and polymeric films. For buccal wound and inju...

Objectives: Corn silk (Stigma maydis) is one part of the corn plant that contains useful chemical compounds, including flavonoid compounds. The ability compounds to capture free radicals cause liver damage. purpose this study was determine hepatoprotective effect ethanol extract on male white rats induced by paracetamol and varying doses as a hepatoprotector.
 Data Sources Study Selection:...

Gynura procumbens is a plant that contains flavonoid compounds as antioxidants and has hepatoprotective effect. A hepatoprotector compound can protect the liver from damage. One way to determine function measure enzyme activity of Serum Glutamic Oxaloacetic Transaminase (SGOT) Pyruvic (SGPT). This study aimed effect extract ethanol on induced by paracetamol toxic dose. used 20 white male rats d...