Aims of Study Lower urinary tract symptoms associated with bladder outlet obstruction include storage and voiding symptoms, and the most bothersome in men with benign prostatic hyperplasia (BPH) is predominantly storage rather than voiding symptoms. Detrusor overactivity, a major cause of irritative symptoms is a common phenomenon in those with BPH. However, the pathophysiology of this detrusor...

PURPOSE Current guidelines recommend α1-adrenoreceptor blockers (A1Bs) for treating lower urinary tract symptoms suggestive of benign prostatic hyperplasia, but their adverse effects can be problematic. In this study, reports submitted to the US Food and Drug Administration Adverse Event Reporting System (FAERS) between 1997 and 2011 were reviewed to assess the safety profiles of A1Bs. METHOD...

Benign prostatic hyperplasia (BPH) is a prevalent disease, especially in old men, and often results in lower urinary tract symptoms (LUTS). This chronic disease has important care implications and financial risks to the health care system. LUTS are caused not only by mechanical prostatic obstruction but also by the dynamic component of obstruction. The exact etiology of BPH and its consequences...

OBJECTIVE To compare the efficacy of two α1 -adrenoceptor antagonists, α1D -adrenoceptor-selective naftopidil (Naf) 75 mg and α1A -adrenoceptor-selective tamsulosin hydrochloride (Tam) 0.2 mg, for the treatment of lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). METHODS Seventy-seven patients with LUTS secondary to BPH were enrolled. Data were gathered from ...

BACKGROUND The newly-synthesized naftopidil analog HUHS1015 suppresses tumor growth and induces apoptosis of cells from a variety of cancer types. The present study was conduced to assess the effect of HUHS1015 on human colonic cancer cells and to clarify the underlying mechanism. RESULTS HUHS1015 reduced cell viability of Caco-2 and CW2 human colonic cancer cell lines in a concentration (0.3...

BACKGROUND Nocturia is defined as waking one or more times during the night due to the urge to void. Recently, the effectiveness of several sedatives and analgesics for nocturia has been reported. We herein investigated the effects of ramelteon, an antioxidant and sleep inducer, on nocturia unresponsive to α1-blocker monotherapy in males with lower urinary tract symptoms (LUTS) as a pilot study...