Endocytosis in endothelial cells (ECs) is important for many biomedical applications, including drug delivery by nano- and microscale carriers. However, little is known about how carrier geometry influences endothelial drug targeting, intracellular trafficking, and effects. We studied this using prototype polymer carriers of various sizes (0.1-10 mum) and shapes (spheres versus elliptical disks...

In the last several decades, cardiovascular diseases (CVDs) have emerged as a major hazard to human life and health. Conventional formulations for treatment of CVD are available, but they far from ideal because poor water solubility, limited biological activity, non-targeting, drug resistance. With advancement nanotechnology, novel delivery approach CVDs has emerged: nano-drug systems (NDDSs). ...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

Nanomaterials are increasingly used as drug carriers for cancer therapy. Nanomaterials also appeal to researchers in the areas of cancer diagnosis and biomarker discovery. Several antitumor nanodrugs are currently being tested in preclinical and clinical trials and show promise in therapeutic and other settings. We review the development of nanomaterial drug carriers, including liposomes, polym...

In this research at the first Metoprolol drug and its fullerene derivative were optimized. Natural bond orbital (NBO), nuclear Indepndent chemical shift (NICS) and finally IR calculations, for these compounds were carried out at the B3LYP/6-31G* quantum chemistry level. Different parameters such as energy levels, the amount of chemical shift in different atoms, the amount of HOMO/LUMO, chemical...

In this research at the first 2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid  drug and its fullerene derivative were optimized. NMR calculations for the complexes were carried out at the B3LYP/6-31G*quantum chemistry level. Different parameters such as energy levels, the amount of Chemical Shift in different atoms, the amount of HOMO/LUMO, chemical potential (µ ), chemical hardness (η)...

Abstract Extracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers. Their physical, chemical and biological characteristics distinguish them unique carriers with specific pharmacokinetic, circulating metabolic, biodistribution patterns in the of therapeutic cargoes. They are critical mediators pathology many diseases, including inflammatory fibrosis, can...

The nano drug delivery system has emerged as a novel therapeutic approach for improved efficacy of the existing molecules. Polymeric nanoparticles, lipid based nanoparticles such solid (SLNs), nanostructured carriers, conjugates, ethosomes, liposomes, and self-emulsifying systems are few carriers used delivery. Among SLNs promising in terms biocompatible carrier enhancing bioavailability, contr...

Niosomes are considered as novel nano-carrier in the drug delivery systems. These much more stable than other nano-carriers like liposomes and nanoparticles. It is an example for targeted control release of medication. The entrapped into lipid core so that it prevents from leaching. Here will be only to desired cell/tissue not non-targeted cells. By giving this formulation we can thereby reduce...