In this contribution we describe the formation of gold nanoparticles (AuNP)and polyaniline (PANI) AuNP-PANI nanocomposite via in situ enzymaticpolymerization. The method consists electrostatic adsorption aniliniummonomers on AuNPs citrate stabilized surface 50 nm diameters, followedby oxidation with horseradish peroxidase (HRP) enzyme and its cofactorH2O2. All reaction steps were monitored by U...

A theranostic agent was successfully fabricated by the formation of Au nanoshell around poly(lactic acid) nanoparticles entrapping doxorubicin, followed by linking a Mn-porphyrin derivative on the Au shell surface through polyethylene glycol. The resulted agent exhibited excellent colloidal stability and long blood circulation time due to introducing polyethylene glycol. The grafting Mn-porphyr...

A quantification method to measure endocytosis was designed to assess cellular uptake and specificity of a targeting nanoparticle platform. A simple N -hydroxysuccinimide ester conjugation technique to functionalize 100-nm hollow silica nanoshell particles with fluorescent reporter fluorescein isothiocyanate and folate or polyethylene glycol (PEG) was developed. Functionalized nanoshells were c...

Fluorescence cell imaging can be used for disease diagnosis and cellular signal transduction. Using a metal nanoshell as molecular imaging agent, we develop a cellular model system to detect CXCR4 chemokine receptor on T-lymphatic cell surface. These metal nanoshells are observed to express enhanced emission intensity and shortened lifetimes due to the near-field interactions. They are covalent...

Nanoshells, which are thin coatings deposited on core particles of different material have gained considerable attention. These materials show novel properties which are different from their single-component counterpart. By simply tuning the core to shell ratio, the properties can be altered. With emerging new techniques it is now possible to synthesize these nanostructures in desired shape, si...

Hollow nanoshells of layered double hydroxide (LDH) have been fabricated using exfoliated LDH nanosheets as a shell building block and polystyrene beads as a sacrificial template.

: We theoretically study the properties of the optimal size distribution in the ensemble of hollow gold nanoshells (HGNs) that exhibits the best performance at in vivo biomedical applications. For the first time, to the best of our knowledge, we analyze the dependence of the optimal geometric means of the nanoshells' thicknesses and core radii on the excitation wavelength and the type of human ...