February 2011 saw the emergence of Silk Road, the first successful online anonymous marketplace, in which buyers and sellers could transact with anonymity properties far superior to those available in alternative online or offline means of commerce. Business on Silk Road, primarily involving narcotics trafficking, rapidly boomed, and competitors emerged. At the same time, law enforcement did no...

This paper presents an overall review of epidural and intrathecal narcotics. The early laboratory studies and initial clinical applications are presented. This is followed by a description of the mechanism of action of narcotics acting both intrathecally and epidurally, and some of the similarities and differences between narcotics and local anesthetic drugs. Technique, dosages, indications, an...