BACKGROUND The prevalence of neonatal abstinence syndrome (NAS) is increasing globally resulting in an increased incidence of adverse neonatal outcomes and health system costs. Evidence regarding the effectiveness of NAS prevention and management strategies is very weak and further research initiatives are critically needed to support meta-analysis and clinical practice guidelines. In NAS resea...

This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety and efficacy data for a larger multi-center trial. This randomized, double-blind, double-dummy, flexible dosing, parallel-group controlled trial was conducted in a comprehensive drug-treatment facility t...

Many European countries have developed National Adaptation Strategies (NAS) to guide adaptation to the expected impacts of climate change. There is a need for more structured communication of the uncertainties related to future climate and its impacts so that adaptation actions can be planned and implemented effectively and efficiently. We develop a novel uncertainty assessment framework for co...

Objective(s): Arachidonic Acid/5-lipoxygenase (AA/5-LOX) pathway connects lipid metabolism and proinflammatory cytokine, which are both related to the development and progression of nonalcoholic fatty liver disease (NAFLD). Therefore, the present study was designed to investigate the role of AA/5-LOX pathway in progression of NAFLD, and the effect of zileuton, an inhibitor of 5-LOX, in this mod...

The NAS Kernels Benchmark Program (NASKER) has been used to measure performance on the Cray C90, Cray Y-MP, Cray-2, Alliant FX/2800 and Connection Machine 2 computer systems. The ground rules for this test are reiterated, with some changes from the original proposal. On each system, tests are performed using varying numbers of processors. Performance results are presented at various tuning leve...

BACKGROUND Despite increased incidence of neonatal abstinence syndrome (NAS) over the past decade, minimal data exist on benefits of parental presence at the bedside on NAS outcomes. OBJECTIVE To examine the association between rates of parental presence and NAS outcomes. METHODS This was a retrospective, single-center cohort study of infants treated pharmacologically for NAS using a roomin...

N-acetylserotonin (NAS) is an immediate precursor of melatonin, which we have reported is neuroprotective against ischemic injury. Here we test whether NAS is a potential neuroprotective agent in experimental models of ischemic injury. We demonstrate that NAS inhibits cell death induced by oxygen-glucose deprivation or H2O2 in primary cerebrocortical neurons and primary hippocampal neurons in v...

OBJECTIVES The objectives of this study were to investigate factors associated with the development of neonatal abstinence syndrome (NAS) and to assess the implications for healthcare resources of infants born to drug-misusing women. DESIGN Retrospective cohort study from 1 January 2004 to 31 December 2006. SETTING Inner-city maternity hospital providing dedicated multidisciplinary care to ...

Unmanned aircraft systems (UAS) can be used for scientific, emergency management, and defense missions, among others. The existing federal air regulations, procedures, and technologies do not allow routine UAS access to the National Airspace System (NAS), with the UAS being flown primarily within restricted airspaces. The current Certificate of Waiver of Authorization (COA) process requirement ...

There is increasing international interest in naphthenic acids (NAs, classical formula C(n)H(2n+Z)O(2)) found in the oil sands from Alberta, Canada and in petroleum from around the world. The complexity of NAs poses major analytical challenges for their quantification and characterization. We used ultrahigh resolution electrospray ionization Fourier transform ion cyclotron resonance mass spectr...