Plants and microbes contain a largely unexploited storehouse of phytotoxins that might be used directly or as structural indicators for new synthetic herbicides. Several factors have increased the interest of the herbicide industry in this source of natural products as herbicides. Natural compounds have made a large impact in the area of insecticides, whereas relatively minor successes have bee...

To prevent and treat diseases caused by the spread of microbes, humans have invented all sorts of effective antimicrobial substances. The most widely used antimicrobial substance is antibiotics. However, misuse of antibiotics can generate various negative effects, bacterial resistance, decreased immunity, and internal flora imbalance which can lead to endogenous infection. In addition, existing...

Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangr...

Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytodrugs and some medicinal herbs have proven hepatotprotective potential. Silymarin, a flavonol lignan mixture) extracted from the Silybum marianum (milk thistle) is a popular remedy for hepatic diseases. Today every herbal company is marketing formulations for liver disorders but th...

Rhizopodin (1, Scheme 1) is an architecturally unique polyketide macrolide that was originally isolated from the myxobacterium Myxococcus stipitatus by the groups of Hçfle and Reichenbach. It shows potent antifungal and antiproliferative cytotoxicity against a range of tumor cell lines with IC50 values in the low nanomolar range. [1] On a molecular level, 1 disrupts the cytoskeleton of actin by...

1Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 2Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA 3Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA 4Division of Infectious Diseases, Cincinnati Children’s Hospit...

1Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece 2Institute of Technology of Agricultural Products, Hellenic Agricultural Organization-DEMETER, 15310 Athens, Greece 3Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AD, UK 4School of Biomedical Scienc...

Throughout human history, natural products—including terrestrial plants, animal products, marine organisms, and products of microorganismal fermentation—have been used in traditional medicines. This historical experience with natural products as therapeutic agents has evolved to sophisticated isolation of active chemical entities from ethnopharmacological plants with the effect that, in modern ...

Crude extracts from Warburgia ugandensis Sprague, Azadirachta indica, Tagetes minuta and Urtica massaica have been tested against soil pathogens; Fusarium oxysporum, Alternaria passiflorae and Aspergillus niger. The results obtained showed biological activity against these pathogens except for U. massaica extract, which was not active. Separation of the crude extract from W. ugandensis yielded ...

Thrombosis is considered to be closely related to several diseases such as atherosclerosis, ischemic heart disease and stroke, as well as rheumatoid arthritis, hyperuricemia, and various inflammatory conditions. More and more studies have been focused on understanding the mechanism of molecular and cellular basis of thrombus formation as well as preventing thrombosis for the treatment of thromb...