Clusterin is a 75-80 kDa heterodimenc glycoprotein that was first identified as a component of the fluid from the ram rete testes (Fritz et al, 1983). Over the past 15 years, the protein has been purified, or its cognate mRNA cloned, from a number of different species and diverse tissues, including several tissues of the reproductive tract (see Table 1). The role, or, more probably, roles, of t...

V oltage-gated ion channels are fascinating micromachines responsible for all electrical signaling in biology. In PNAS, Amaral et al. (1) use molecular simulations to show how the new NavAb sodium channel from Arcobacter Butzleri (2) moves between intermediate states similar to K channels, which means it is likely that these principles are generally valid for activation of voltage-gated ion cha...

genetic protein expression in human atherosclerotic lesions. J Clin Invest 1993;91: 1800–9. 39. Hirota S, Imakita M, Kohri K, Ito A, Morii E, Adachi S et al. Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. A possible association with calcification. Am J Pathol 1993;143:1003–8. 40. Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH et al....

background : almost two thirds of iranians eligible for using contraceptive methods use these methods. their dissatisfaction with the methods would directly and indirectly affect the quality of family planning services and would bring about detrimental results for the service recipients and consequently for other family members. therefore, identification and evaluation of the factors leading to...

heart rate in determining the occurrence and frequency of myocardial ischemia during daily life in patients with stable coronary artery disease. J Am Coll Cardiol 1992;20:1092–1098. 28. Ingwall JS, Weiss RG. Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res 2004;95:135–145. 29. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH...

Real-time in-situ visualization of virtual data overlaid on its real counterpart is getting increasing attention. Augmented Reality (AR) for intra-operative visualization and navigation has been a subject of intensive research and development during the last decade [2], [9], [12]. Besides accuracy and speed of the system one of the challenges to improve acceptance of medical AR systems is the l...

Serum cholesterol is carried by several lipoprotein parti-Medicine and Atherosclerosis cles that perform the complex physiologic tasks of * Department of Medicine transporting dietary and endogenously produced lipids Division of Endocrinology and Metabolism (reviewed in Witztum and Steinberg, 1995). Chylomicrons † Department of Cellular and Molecular Medicine provide the primary means of transp...