Granulomatosis with polyangiitis (GPA, formerly Wegener granulomatosis) is a vasculitis with various organ involvement. There have been a few cases of CNS stroke and rare cases of lateral medullary infarction (LMI) as a manifestation of GPA. Also there have been reports of sinuses, nose and laryngeal masses mistakenly referred as carcinomas and subsequently GPA was diagnosed in their pathologic...

Methotrexate (MTX) is an antimetabolite which interferes with DNA synthesis, and it is used for the treatment of moderate to severe psoriasis, atopic dermatitis and a wide variety of cutaneous diseases. Although many adverse effects of MTX, including cutaneous ulcerations, have been documented, multifocal mucosal ulceration mimicking Behçet's disease has not been reported. In our case, a 63-yea...

Scleromalacia perforans is most frequently associated with rheumatoid arthritis. A necrotizing nodular scleritis proceeding to scleromalacia perforans is sometimes seen in the collagen disorders systemic lupus erythematosus, periarteritis nodosa, and Wegener's granulomatosis. Rarely scleromalacia has been described in porphyria and herpes zoster (Duke-Elder and Leigh I 965; Fran§ois, I 95 1) . ...

Scleromalacia perforans is most frequently associated with rheumatoid arthritis. A necrotizing nodular scleritis proceeding to scleromalacia perforans is sometimes seen in the collagen disorders systemic lupus erythematosus, periarteritis nodosa, and Wegener's granulomatosis. Rarely scleromalacia has been described in porphyria and herpes zoster (Duke-Elder and Leigh I 965; Fran§ois, I 95 1) . ...

Methotrexate is a folic acid antagonist and immunosuppressive agent, which is being increasingly used in various ocular inammatory diseases. Its use in ophthalmology has been increasing in recent years because of its anti-inammatory activity and corticosteroid-sparing objective. It is currently used in recurrent anterior uveitis, intermediate uveitis, posterior or panuveitis, scleritis, perip...

PURPOSE To investigate the safety, tolerability and efficacy of subconjunctival sirolimus injections as a treatment for active, autoimmune, non-necrotizing anterior scleritis. DESIGN Phase I/II, single-center, open-label, nonrandomized, prospective pilot study. METHODS Five participants with active, autoimmune, non-necrotizing anterior scleritis with scleral inflammatory grade of ≥1+ in at ...

• Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome The respiratory system is commonly involved in all three syndromes, which share certain histopathologic and clinical features. Other features are unique and diseasedefining (Table 1). Diffuse alveolar hemorrhage (Figure 1, A1, see page 2) is a potentially life-threatening complication of each of the...