Background The use of paracetamol or nefopam for postoperative pain control is limited by the need high doses associated with unwanted effects. Previous works suggest positive interactions between both compounds that may be exploited to obtain potentiation antinociception. Methods Mechanical and heat antinociception induced oral paracetamol, their combination was studied isobolographic analysis...

We studied 90 adults undergoing surgical removal of at least both lower third molar teeth as day cases under standardized general anaesthesia. Patients were allocated randomly (with stratification for surgeon) to receive tenoxicam 40 mg, tenoxicam 20 mg or placebo i.v. at induction of anaesthesia and orally (effervescent tablets) with food on each of the subsequent 2 days. Panadeine (paracetamo...

La consommation de néfopam est en constante augmentation France. Les objectifs cette étude sont quantifier l’intensité du signal pharmacodépendance, d’identifier les populations à risque et facteurs survenue. L’ensemble des cas graves non d’abus, d’usage détourné, surdosage syndrome sevrage rapportés au réseau français Centres d’addictovigilance, depuis 1988, a été analysé, ainsi que données re...

BACKGROUND Hospitalised older patients are complex. Comorbidity and polypharmacy complicate frailty. Significant numbers have dementia and/or cognitive impairment. Pain is highly prevalent. The evidence base for pain management in cognitively impaired individuals is sparse due to methodological issues. A wealth of expert opinion is recognised potentially providing a useful evidence base for gui...

OBJECTIVE To study the pharmacokinetics and comparative bioavailability of nefopam tablets (Acupan®). SUBJECTS AND METHODS Experimentation of this study was based on a single-dose, two-sequence, cross-over randomized design using 12 fasting healthy Pakistani male young subjects. This validated LC/MS method was applied to a pharmacokinetic and bioavailability study in 12 fasting healthy Pakist...