administration of endotracheal surfactant is potentially the main treatment for neonates suffering from rds (respiratory distress syndrome), which is followed by mechanical ventilation. late and severe complications may develop as a consequence of using mechanical ventilation. in this study, conventional methods for treatment of rds are compared with surfactant administration, use of mechanical...

Bronchopulmonary dysplasia (BPD), also known as chronic lung disease (CLD), is the most common serious morbidity associated with premature birth, particularly among those infants who have respiratory distress syndrome (RDS) and receive mechanical ventilation after birth. BPD is characterized by lung inflammation and scarring, which are thought to be the effects of excessive (or inadequate) vent...

From 1976 to 1980, 1034 children who had weighed less than 2001 g at birth were cared for at the North Western regional neonatal intensive care unit. Of these, 315 babies were neonatal referrals and 91 were born in the unit after antenatal transfer from their district hospital. Significantly fewer of the babies referred as neonates survived (n = 167, 53%) compared with 67 of the antenatal refer...

As in the adult with acute lung injury and acute respiratory distress syndrome, the use of lung-protective ventilation has improved outcomes for neonatal lung diseases. Animal models of neonatal respiratory distress syndrome and congenital diaphragmatic hernia have provided evidence that 'gentle ventilation' with low tidal volumes and 'open-lung' strategies of using positive end-expiratory pres...

Ventilator-associated pneumonia (VAP) is a serious complication related to mechanical ventilation in the neonatal period. However, lack of a specific definition and difficulties obtaining noncontaminated samples of the lower respiratory airway render microbiological diagnosis and etiological treatment extremely difficult. Thus far, only few studies have approached VAP using accepted Centers for...

Objects: The purpose of this study was to observe a correlation between PETCO2 and PaCO2 in intubated neonates under intermittent mandatory ventilation with spontaneous breathing. Material and methods: A total of 55 paired PETCO2 measured by mainstream capnometry and PaCO2 values were obtained from 4 intubated neonates in our neonatal intensive care units at Nagano Children’s Hospital, Nagano, ...

OBJECTIVE To identify risk factors for extubation failure and reintubation in newborn infants subjected to mechanical ventilation and to establish whether ventilation parameters and blood gas analysis behave as predictors of those outcomes. METHODS Prospective study conducted at a neonatal intensive care unit from May to November 2011. A total of 176 infants of both genders subjected to mecha...

We recorded the respiratory history by questionnaire in a 7 year old cohort of children whose birth weight was under 2000 g and an unselected reference group of local schoolchildren of the same age. Complete data were obtained in 121 low birthweight children (90% of those studied): 62 who had no neonatal respiratory illness, 25 who had oxygen treatment only, and 34 who received mechanical venti...

IMPORTANCE Extubation failure is common in extremely preterm infants. The current paucity of data on the adverse long-term respiratory outcomes associated with reinitiation of mechanical ventilation prevents assessment of the risks and benefits of a trial of extubation in this population. OBJECTIVE To evaluate whether exposure to multiple courses of mechanical ventilation increases the risk o...

Important breakthroughs in neonatology, particularly in prevention and treatment of respiratory disorders, have extended the limits of viability to lower gestational ages. Despite these advances, conventional mechanical ventilation (CMV) (usually pressure-limited intermittent mandatory ventilation in neonates) remains an essential therapy in neonatal intensive care. Advances in CMV, exogenous s...