The immune response of the neonate is poor and is dependent on passive immunity provided by maternal Ig. However, here we show that exposure of the neonate to environmental antigens induces a germinal center (GC) reaction. In the peripheral blood of premature infants one finds IgG class switched B cells expressing a selected V-gene repertoire. These data suggest that restrictions in the reperto...

1. Describe the association between gestational age, birthweight, and postnatal age and blood pressure in the neonate. 2. Delineate the primary clinical consideration in an infant who has hypotension. 3. Describe the controversy surrounding the relationship between antenatal steroid therapy and neonatal blood pressure. 4. Delineate the aspects of management of respiratory illnesses in the neona...

anxiety during pregnancy: a risk factor for neonatal physical outcome? alipour z1, lamyian m*2, hajizadeh e3 received: 25 april, 2010 accepted: 27 july, 2010 abstract background & aims: antenatal maternal anxiety is common during pregnancy and may have side effects on mother and neonate. the aim of this study was to evaluate the relationship between maternal anxiety and neonatal outcomes in nul...

Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary bypass adapted for long-term use. Blood is drained from the patient, pumped through an artificial lung or membrane where gas exchange is augmented, and then re-infused back to the patient. ECMO provides support for the neonate with severe respiratory failure so that potentially deleterious ventilator settings can be minimiz...

Background: Congenital diaphragmatic hernia (CDH) is a simple diaphragmatic defect that is seen frequently in antenatal scans. Though the surgical repair is relatively easy in the neonate, the mortality is high due to pulmonary hypoplasia and pulmonary vascular changes. Materials and Methods: The goals of prenatal imaging are to establish the diagnosis. Assessment in a tertiary scanning center ...

Despite the significant advancement of minimally invasive surgery (MIS) in the adults and even in pediatric population, its role as the standard of care in the neonates has not yet been established among the pediatric and neonatal surgeons universally. Lots of controversies still arise though several advanced centers in the world having very experienced surgeons performing MIS for neonatal surg...

A neonate with severe oligo-anuric renal failure during multi-organ failure survived with prolonged renal replacement therapy Sir, Here, we report a neonate with severe oligo-anuric renal failure during multi-organ failure who survived with prolonged renal replacement therapy. A female neonate, born at a gestational age of 39 weeks and 3 days, weighing 2780 gram, presented cyanosis on Day 15. S...

Introduction: Repeat antenatal corticosteroids may reduce respiratory distress syndrome however there is conflicting evidence suggesting it may be unnecessary or harmful. This article reviews the literature to examine the role of multiple courses of antenatal steroids to prevent neonatal respiratory distress syndrome. Methods: Electronic databases were searched online. Results: Four randomised ...

Asthma affects 8–9% of pregnant women in the USA [1]. Since asthma exacerbations during pregnancy can lead to poor pulmonary function, hypoxia and other adverse health outcomes for the mother, fetus and neonate [2, 3], maintaining good control of asthma during pregnancy is recommended for the health of both mother and baby [4]. Reviews of the safety of asthma medication use during pregnancy sug...