In the recent years, the role of LOX enzymes in the cause of neoplastic diseases such as colorectal, skin, pancreatic and renal cancers has been confirmed. A new series of 1,3,4-thiadiazole derivatives bearing 2-pyridyl moiety was synthesized and their cytotoxicity was assessed using MTT protocol. Enzyme inhibitory activity of prepared compounds was also tested against 15-lipoxygenase-1 as nove...

A fundamental prediction of the hypothesis that critical events in tumour formation are rare is that the tumours develop by clonal expansion. This prediction has been tested by establishing the isozyme content of tumours induced in mosaic animals whose normal tissues contain two distinguishable isozyme activities. The observation that tumours contain activity associated with one or other of the...

OBJECTIVE A micronucleus is a small additional nucleus formed due to chromosomal loss or fragmentation. The aim of this study was to assess the utility of micronucleus count as a screening tool in cervical cancer. MATERIAL AND METHOD A total of 132 cases consisting of 42 pre-neoplastic and neoplastic cases and 90 non-neoplastic cases were studied. Only routine Papanicolaou-stained cervical sm...

BACKGROUND To determine the origin of the neoplastic cell in central nervous system (CNS) hemangioblastomas in von Hippel-Lindau disease (VHL) and its role in tumor formation and distribution, we characterized and differentiated neoplastic cells from hemangioblastomas removed from VHL patients. METHODS AND FINDINGS A total of 31 CNS hemangioblastomas from 25 VHL patients were resected and ana...

in the recent years, the role of lox enzymes in the cause of neoplastic diseases such as colorectal, skin, pancreatic and renal cancers has been confirmed. a new series of 1,3,4-thiadiazole derivatives bearing 2-pyridyl moiety was synthesized and their cytotoxicity was assessed using mtt protocol. enzyme inhibitory activity of prepared compounds was also tested against 15-lipoxygenase-1 as nove...

Canine lymphoma is the most common neoplasm of the hematopoietic system with the most frequently diagnosed malignancy. Also, dogs affected by T-cell lymphoma displayed a lower rate of complete chemotherapy response and have a high risk of death in the early stage of the disease. A 5-year-old male mixed dog was presented to the Small Animal Hospital, School of Veterinary Medicine, Shiraz Univers...

Objective: To determine the association between inflammatory mast cells and various diseases of salivary glands.
 Material Methods: An experimental lab based descriptive study was done at institute pathology diagnostic medicine, Khyber medical university, Peshawar. Non probability, convenient sampling comprising n=71was tissue biopsies gland were collected from April, 2022 to Sept. 2022. G...

Background & Objective: Abdominal cutaneous and subcutaneous nodules are uncommon lesions which may be benign or malignant. Majority of the malignant nodules are metastatic in origin and may be the initial presentation of primary malignancy, hence an early diagnosis is important. Our aim was to find out the spectrum of lesions (both non-neoplastic and neoplastic) that present as cutaneous and s...

Multiple myeloma (MM) is predominantly composed of well-differentiated neoplastic plasma cells morphologically resemble non-neoplastic plasma cells. However, some rare cytological variants of MM, such as polymorphous, pleomorphic, plasmablastic, signet-ring cell, smallcell, histiocytoid cell, clear cell, and spindle cell variants, have been reported [1]. Plasmablastic myeloma is characterized b...