Simultaneous combined superficial peroneal nerve and peroneous brevis muscle biopsy, via the same cutaneous incision, allows examination of several tissue specimens and significantly improves the diagnosis of systemic diseases with peripheral nerve involvement. Vasculitides are certainly the most frequently diagnosed on neuro-muscular biopsies, but this procedure is also well advised to asses a...

An 81-year-old woman presented with light perception vision in her left eye and had pallid swelling of the left optic disk. Temporal artery biopsy was normal. Magnetic resonance imaging revealed enlargement and enhancement of the left orbital optic nerve. There were vitreous cells, but a vitrectomy specimen showed only a benign lymphocytic population. Her vision deteriorated to no light percept...

A case of infantile metachromatic leucodystrophy is described in which symptoms started at 1 year of age with weakness and hypotonus in the lower extremities. The electrophysiological status was typical of a polyneuropathy, showing fibrillation and a reduction of the nerve conduction velocity to 30 percent of the average for normal children of the same age. Clinical signs of a central lesion an...

A 33-year-old man with acute myelogenous leukemia developed a rapidly progressive painful neuropathy with symmetric sensorimotor and autonomic deficits 7 weeks after chemotherapy. Nerve conduction studies showed axonal sensorimotor neuropathy. Because of the rapidly progressive course, a sural nerve biopsy was performed, which showed intraneural leukemic infiltrates (figure). This case illustra...

A 16-years-old female patient with painless swelling of the right side of mandible is described. She noticed the swelling from two years ago, without painful symptoms. Axial CT imaging showed buccal expansion with intact buccal and lingual cortical bone. The report of incisional biopsy was central odontogenic fibroma. Under general anesthesia the lesion was removed after ostectomy of buccal cor...

Comprehensive electrophysiological studies were performed on 13 patients with arsenic neuropathy. The most prominent finding was a marked abnormality in sensory nerve conduction in the presence of moderate abnormalities in motor nerve conduction. The motor nerve conduction studies and needle EMG were typical of those seen in axonal degeneration which was confirmed by sural nerve biopsy.

OBJECTIVES To detect post-operative sequelae of sural nerve biopsy. MATERIALS AND METHODS A questionnaire mailed to type 1 diabetic patients (n = 24; male/female 23/1; reply n = 23) 2 years after biopsy. RESULTS Type 1 diabetic patients (age 56 [11]; median [interquartile range]) had a long duration of diabetes (DM; 20 [19] years) and all had neuropathy. Three out of 24 patients developed i...

Peripheral nerve hyperexcitability is a rare disorder characterized by spontaneous motor unit activity. Although peripheral seen in multiple immune-mediated neurological conditions, an association with dermatomyositis has rarely been reported. We present 65-year-old woman serological and muscle biopsy features of who also developed marked hypertrophy, stiffness, delayed relaxation along electro...

Patients with leprosy may have only nerve involvement without skin changes. These cases are known as pure neural leprosy and can be seen in 10% of leprosy patients. Most patients have mononeuritic or multiple mononeuritic neuropathy patterns. The isolated lesion of the superficial peroneal nerve is uncommonly seen. We report a patient with involvement of this nerve in which there was no thicken...

Postherpetic neuralgia (PHN) is a common and exceptionally drug-resistant neuropathic pain condition. In this cross-sectional skin biopsy study, seeking information on the responsible pathophysiological mechanisms we assessed how ophthalmic PHN affects sensory and autonomic skin innervation. We took 2-mm supraorbital punch skin biopsies from the affected and unaffected sides in 10 patients with...