OBJECTIVE To compare the characteristics and prognosis of patients with malignant (necrotizing) external otitis (MEO) with and without facial nerve palsy in today's era of third-generation antibiotics. DESIGN Comparative retrospective case series. SETTING Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, a tertiary care medical center. PATIENTS Forty-eight patients...

Malignant gliomas are characterized by infiltrative growth of tumor cells, including along white matter tracts. This may result in clinical cranial neuropathy due to direct involvement of a cranial nerve rather than by leptomeningeal spread along cranial nerves. Gliomas directly involving cranial nerves III-XII are rare, with only 11 cases reported in the literature before 2014, including 8 wit...

OBJECTIVE To characterize peripheral nerve involvement in patients with chronic progressive external ophthalmoplegia (CPEO) with single and multiple mitochondrial DNA (mtDNA) deletions, based on clinical scores and detailed nerve conduction studies. METHODS Peripheral nerve involvement was prospectively investigated in 33 participants with CPEO (single deletions n = 18 and multiple deletions ...

Leprosy is primarily a disease of the nerves. Mycobacterium leprae infects the Schwann cells (SC) that surround the nerve fibres and axons. Leprosy is a complex disease known for having great variability in its clinical presentation, sometimes with more nerve involvement and related anesthesia and deformities and sometimes with skin lesions primarily. In about 4–8% of the cases the clinical pre...

Neurolymphomatosis (NL) is a rare disease that can be caused by T cell, B cell or natural killer cell (NK) lymphomas, but most commonly by B cell lymphomas.1 NL is characterized by direct infiltration of the central nervous system (CNS), nerve roots/plexus or peripheral nerves by a hematological malignancy.2–4 Multiple nerve involvement is more common than single nerve involvement.1 Secondary N...

petrous apex lesions of temporal bone progress slowly. most of the time not only destruct this area but also involve neighbouring element. the symptoms of the neighbouring neuro-vasculare involvement we can recognize these lesions. the most common symptoms of involvement of the petrous apex are: headache, conductive hearing loss or sensorineural type, paresthesia and anesthesia of the trigemina...

primary nasopharyngeal tuberculosis (tb) without pulmonary involvement is rare, even in endemic areas. herein, we present a rare complication of primary nasopharyngeal tb accompanied with tuberculous otomastoiditis (tom) and ipsilateral facial nerve palsy, in a 24-year-old female patient, with computed tomography and magnetic resonance imagery findings.

leptospirosis, a disease of great significance in tropical countries, presents commonly as a biphasic illness with acute febrile episode in the first phase followed by a brief afebrile period and then by the second phase of fever with or without jaundice and renal failure. however, it has varied manifestations and unusual clinical features ascribed to immunological phenomena can occur due to th...

Purpose. To report the ocular findings in patients with hematopoietic malignancy with optic nerve involvement and abducens nerve palsy. Methods. The medical records of all cases of hematopoietic cancer with ophthalmic involvements seen in the Department of Ophthalmology of the National Center for Global Health and Medicine between 2009 and 2014 were reviewed. Results. Eight patients with hemato...

An unsuspected uveal melanoma arising in a phthisical eye extended through the optic nerve to the surgical margin in the orbital apex without involvement of other orbital structures. Step sections showed the continuous extension through the nerve. Factors likely to predispose to optic nerve extension include epithelioid cell type, large tumour size, peripapillary involvement, and glaucoma. Opti...