• Although, it is assumed that digitalis glycosides are relatively ineffective in heart failure and atrial fibrillation associated with disorders of thyroid gland function," there is little experimental work to support this belief. Frye and Braunwald observed that administration of triiodothyronine to euthyroid and hypothyroid patients with chronic atrial fibrillation increased the dose of card...

IN 1963 a study was published from our laboratory concerning cardiac performance during exercise before and after conversion from atrial fibrillation to sinus rhythm.' All subjects were receiving digitalis at the time of conversion. One of the findings of that study was a markedly low heart rate at exercise in sinus rhythm, much lower than expected for a group of subjects with a comparable degr...

ATRIAL TACHYCARDIA with atrioventricular block was first described by Sir Thomas Lewis in 1909.1 In recent years, Lown, Levine, and co-workers2-5 have emphasized the importance of digitalis intoxication as a cause of this arrhythmia. Other authors have also supported this concept.6' 7 Two large series describing the arrhythmia were published in 1943. Barker and coworkers8 found that digitalis w...

Background: Pre-eclampsia is an idiopathic pregnancy disorder characterized by appearance proteinuria and hypertension, with poorly understood etiology. It has been linked to a variety of system abnormalities, including ion transport disorders in neonatal, maternal, and placental cell lines. A new method was described to evaluate the inhibition percentage of endogenous digitalis in plasma of pr...

The treatment of paroxysmal supraventricular tachycardia (PSVT) in infancy with digitalis, adenosine triphosphate (ATP) and verapamil is reported. Treatment was successful in about 90% of the patients treated with ATP and verapamil and in 61--71% of the patients treated with digitalis (Lanatoside C). Verapamil terminated the tachycardia within 2 minutes of administration in most instances and A...