BACKGROUND Organic solvents are known as a group of organic compounds, widely used in industry and to which many workers are exposed. Neurotoxicity is one of the most important complications of the chronic exposure to the solvents and may causes neurobehavioral disorders in workers. We have studied the frequency of neurobehavioral disorders in workers exposed to organic solvents in one of the p...

At picomolar concentrations, lead activates protein kinase C (PKC). This activation has been implicated in the neurotoxicity of lead. No prior study has evaluated the association of PKC activity with neurobehavioral function in humans. The purpose of this study was to determine whether PKC activity is associated with neurobehavioral function or modifies the relationship between blood lead level...

STUDY OBJECTIVES Sleep deprivation, time of day (circadian influences), and obstructive sleep apnea (OSA) all reduce performance and neurobehavioral function. We assessed the interactive effect of sleep deprivation and time of day on performance and neurobehavioral function in subjects with and without mild OSA. METHODS This was a cross-over study in which 13 subjects with mild OSA and 16 sub...

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most frequent neurobehavioral syndrome in childhood, causing significant impairment family, social and academic performance of children. A tool to help both diagnosis follow-up schoolchildren SNAP-IV scale, which evaluate 18 behaviors, according answers parents and/or teachers.

The ontogeny of fetal autonomic, motoric, state, and interactive functioning was investigated longitudinally in a sample of 31 healthy fetuses from 20 weeks through term. Fetal heart rate and movement data were collected during 50 min of doppler-based fetal monitoring at 6 gestational ages. Measures of fetal heart rate and variability, activity level and vigor, behavioral state, and reactivity ...

Martin Farlow MD, editor. Dr. Farlow of Indiana University School of Medicine received research grant support from BristolMyersSquibb, Danone, Eisai, Elan, Eli Lilly, Genentech, Novartis, OctaPharma, Pfizer, Roche, Sanofi-Aventis, and Sonexa; honorariums from Eisai, Forest Laboratories, Pfizer, and Novartis for speaking engagements; and fees from Accera, Alltech, Astellas, Baxter Healthcare, Ba...