The system of classification and terminology neuroendocrine neoplasms (NENs), updated in 2017 by AJCC 2019 WHO, is now recommended for general use. This article a review this with respect to NENs the digestive tract. Within new system, two categories were introdu­ced, differing morphology, clinical course treatment, as based on differentiation histological maturity grading (G). Among tract, wel...

There are several differences between neuroendocrine and other types of cervical cancer, in prognosis, diagnosis and treatment. Neuroendocrine cancer of the uterine cervix is a rare and aggressive disease. Small cell carcinoma is classified as a neuroendocrine tumor in the currently used World Health Organization histological classification of tumors of the uterine cervix (2003). Small-cell car...

Neuroendocrine tumours are a heterogonous group of tumours with a wide variety of clinical presentations. They arise from enterochromaffin cells located in neuroendocrine tissue throughout the body. Neuroendocrine tissue is derived from cells which migrated from the neural crest to the gastrointestinal endoderm. There are many types of NETs, phaeochromocytoma’s, small cell carcinoma’s of the lu...

Neuroendocrine adenomas of the middle ear (NEAME) are rare tumors.1-4 Whereas neuroendocrine cells are normally found in the lung and gastrointestinal tract, they are normally not found in the middle ear (ME) mucosa.1-6 Although neuroendocrine tumors were initially believed to originate from the neuroendocrine cell system, it is now known that they may originate from tissue that lacks neuroendo...

INTRODUCTION Small cell neuroendocrine cancer of the breast is a rare tumor with less than 30 cases reported in the literature. The morphological and immunohistochemical patterns of this tumor are similar to small cell neuroendocrine cancer of the lung. For this reason, it is often difficult to distinguish a primary small cell neuroendocrine cancer of the breast from a metastatic lesion from ot...