introduction: gap junctions are intercellular membrane channels that provide direct cytoplasmic continuity between adjacent cells. this communication can be affected by changes in expression of gap junctional subunits called connexins (cx). changes in the expression and function of connexins are associated with number of brain neurodegenerative diseases. neuroinflammation is a hallmark of vario...

Neuroinflammation is a key feature of Alzheimer's disease (AD), progressive neurodegenerative disorder. Microglia, the resident immune cells central nervous system, play crucial role in pathogenesis AD and are active participants neuroinflammation. Adequate reproduction neuroinflammation animal models one main methodological approaches for studying pathophysiology. The aim study was to conduct ...

Introduction: Gap junctions are intercellular membrane channels that provide direct cytoplasmic continuity between adjacent cells. This communication can be affected by changes in expression of gap junctional subunits called Connexins (Cx). Changes in the expression and function of connexins are associated with number of brain neurodegenerative diseases. Neuroinflammation is a hallmark of vario...

The development of new drugs to combat neuroinflammation is highly relevant as it opens up possibilities for the treatment a wide range diseases, including Alzheimer’s disease, Parkinson’s epilepsy, schizophrenia, depression, and others. Kappa-opioid agonists represent promising class compounds with а high potential be used in neurological conditions accompanied by neuroinflammation. aim study ...