Based upon a thorough review of published clinical observations regarding the inhibitory system, I hypothesize that this system may play a key role in the pathogenesis of a variety of neuromuscular and neurological diseases. Specifically, excitatory overstimulation, which is commonly reported in neuromuscular and neurological diseases, may be a homeostatic response to inhibitory overstimulation...

VĂ˝znamnĂĄ část nosologickĂ˝ch jednotek z okruhu nervosvalovĂ˝ch onemocněnĂ­ vede v určitĂŠ fĂĄzi svĂŠho prĹŻběhu k oslabenĂ­ svalĹŻ dĂ˝chacĂ­ch anebo svalovĂ˝ch struktur hornĂ­ch cest dĂ˝chacĂ­ch. Toto se u velkĂŠ části pacientĹŻ vĂ˝razněji manifestuje vleĹže. NĂĄsledně během spĂĄnku nejčastěji objevuje obstrukčnĂ­ spĂĄnkovĂĄ apnoe a hypoventilace vĂĄzanĂĄ na spĂĄnek, vzĂĄcnějĹĄĂ...

Neuromuscular junctions are primary pathological targets in the lethal motor neuron diseases spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). Synaptic pathology and denervation of target muscle fibers has been reported prior to the appearance of clinical symptoms in mouse models of both diseases, suggesting that neuromuscular junctions are highly vulnerable from the very e...

INTRODUCTION A significant group of neuromuscular diseases are of autoimmune origin, but the classic immunomodulatory drugs are not often effective. For this reason, there is a need to find new more effective treatments that will lead to better control of these conditions, particularly those that are usually more resistant. In the last few years, the use of monoclonal antibodies against specifi...