to compare intubating conditions and hemodynamic changes between bonfils intubation fiberscope and macintosh laryngoscopy without administering neuromuscular blocking drugs (nmbds). methods: in this randomized controlled trial,80 male and female patients, scheduled for elective surgery, aged 15 to 60 years, asa class ii or i, non-obese, non smokers, without anticipated difficult intubation; wer...

Corresponding author: Dr Arsen Uvelin, M.D. Clinical centre of Vojvodina, Emergency Centre, Department of Anaesthesia and Intensive Therapy Hajduk Veljka 1, 21000 Novi Sad, Serbia e-mail: [email protected] Sir, the “timing principle” utilises administration of a single bolus dose of nondepolarizing muscle relaxant (NMR), followed by an induction drug at the onset of muscular weakness (1) was...

The aim of this study was to examine differences in prejunctional effects of different relaxants by measuring the train-of-four (TOF) fade during the onset and recovery of neuromuscular block. The relaxants studied were atracurium (225 micrograms.kg-1), mivacurium (65 micrograms.kg-1) rocuronium (300 micrograms.kg-1) and vecuronium (40 micrograms.kg-1). The TOF ratios were measured at approxima...

Neuromuscular blocking drugs are valuable adjuncts to the practice of pediatrics. Monitoring of drug effects is technically more difficult in the younger patient. Nevertheless, careful observation of drug effects will improve the usefulness of NMB and safeguard the patient from prolonged weakness. Although there are differences in neuromuscular function with age in the pediatric age range, the ...

BACKGROUND The most sensitive diagnostic criterion of myasthenia gravis is a decrement in the muscular response to repetitive stimulation. The authors hypothesized that myasthenia gravis patients who show a train-of-four ratio (T4/T1) < 0.9 in the preanesthetic period will have increased sensitivity to nondepolarizing neuromuscular blocking agents compared with myasthenia gravis patients with p...

BACKGROUND Burn injury leads to resistance to the effects of non-depolarizing muscle relaxants. We tested the hypothesis that a larger bolus dose is as effective as priming for rapid onset of paralysis after burns. METHODS Ninety adults, aged 18-59 yr with 40 (2)% [mean (SE)] burn and 30 (2) days after injury, received rocuronium as a priming dose followed by bolus (0.06+0.94 mg kg(-1)), or s...

BACKGROUND Gentamicin reduces acetylcholine release and clindamycin causes end-plate ion channel blockade. Because of these reasons, two drugs show muscular relaxant effect and potentiate the action of nondepolarizing neuromuscular agents. This study was intended to evaluate the effect of gentamicin and clindamycin on rocuronium-induced neuromuscular blockade and the interaction between these d...

BACKGROUND AND OBJECTIVES The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental studies and in humans. The aim of this study was to evaluate in vitro the interaction between ropivacaine and pancuronium, the influence on tran...