Recent neurological studies have shown the importance of dendrites in neural computation. In this paper, a neuron model with dendrite morphology, called logic dendritic (LDNM), is proposed for classification. This consists four layers: synaptic layer, membrane and soma body. After training, LDNM simplified by proprietary pruning mechanisms further transformed into circuit classifier. Moreover, ...

William Bialek NEe Research Institute 4 Independence Way, Princeton, N J 08540 We develop a model-independent method for characterizing the reliability of neural responses to brief stimuli. This approach allows us to measure the discriminability of similar stimuli, based on the real-time response of a single neuron. Neurophysiological data were obtained from a movementsensitive neuron (HI) in t...

Introduction: The aim of this study was evaluate the ability of notochord to induce neural induction and/or differentiation of mouse embryonic stem cell to neuron and motor neuron, respectively. Methods: In order to produce embryoid bodies, ES cells line Royan B1 were grown in suspension in the absence of LIF for 4 days. EBs were divided into 4 groups. EBs in group 1 & 2 were further cultur...

In our previous tech brief on modeling a simple biomimetic joint, I proposed the use of the integrate-and-fire model as the model for the muscle spindle afferent sensory neurons. In the form presented previously, I used the equation for the ideal I&F neuron. In this tech brief I’d like to extend this model a bit and make it a better representative of our BAN circuit. I will also discuss some no...

Intensive experimental studies have shown that astrocytes are active partners in modulation of synaptic transmission. In the present research, we study neuron-astrocyte signaling using a biologically inspired model of one neuron synapsing one astrocyte. In this model, the firing dynamics of the neuron is described by the Morris-Lecar model and the Ca(2+) dynamics of a single astrocyte explained...

in this research, we have computationally investigated a mechanism for antiepileptic drugs (aed) and proposed bumetanide as a possible temporal lobe epilepsy (tle) treatment. experimentally it is difficult and devastating to determine the ionic mechanisms of depolarizing currents. it is obvious that chlorine and potassium transients are challenging to isolate pharmacologically and much γ-aminob...