Neurofilament light chain (NfL) is an incredibly specific marker of neuronal injury that not for cause or location the damage. NfL increasingly considered as possible biomarker disease activity in neurological conditions. Several works reviewed utility different diseases. Nonetheless, a universal damage, which interpretation spaces beyond single disease. Because this, may benefit by also consid...

In randomly selected chronic alcoholics hospitalised for the first time for detoxification a high prevalence (68%) of cognitive deficits was found. Peripheral neuronal damage was seen in 74%, autonomic neuronal damage in 24%. Cognitive deficits were not correlated with age, daily ethanol intake, duration of alcohol abuse or severity of liver damage. There was no correlation of peripheral, auton...

PURPOSE S100B protein is widely used as a measure of glial activity or damage in several brain conditions. Central nervous system (CNS) infections can cause neurological sequelae because of parenchyma invasion. It is difficult to predict further neuronal damage in the CNS infection. The present study is aimed to evaluate the role of the cerebrospinal fluid (CSF) S100B protein as an indicator of...

The evolution of neuronal damage in various regions during ischemia and in early recovery was investigated morphologically using hyperglycemic and normoglycemic Wistar rats. Hyperglycemia (20-35 mu mol/ml plasma) was achieved with the infusion of glucose (i.v.) prior to ischemia. Forebrain ischemia (10 minutes) was induced by bilateral common carotid artery occlusion and hypotension. Normoglyce...

Several works suggest that oxidative DNA damage and alterations of DNA repair enzymes in neuronal cells contribute to the onset of neurodegenerative diseases and neuronal cancer. Cadmium is a common environmental pollutant able to induce oxidative stress leading to the activation of neuronal death pathways and it is also able to inhibit specific DNA repair enzymes of the BER (Base Excision Repa...

BACKGROUND AND PURPOSE We examined the density and distribution of brain damage after repeated periods of nonlethal ischemic insult in rats in comparison with damage after single lethal periods of ischemic insult. METHODS Transient cerebral ischemia was induced by four-vessel occlusion for 3, 10, 20, and 30 minutes, and 3-minute periods of ischemia were repeated two, three, or five times at 1...

background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...

it has been estimated that more than 1.7 million individuals suffer a traumatic brain injury (tbi) each year. tbi causes secondary biochemical and metabolic changes which contribute to subsequent tissue damage and associated neuronal cell death. two early and delayed events occur after tbi, which results in neurological deficits. primary injury events include the mechanical damage that occur at...

Objective(s):The major objective of the present study was to investigate the potential neuroprotective effect of berberine chloride on vascular dementia. Berberine, as an ancient medicine in China and India, is the main active component derived from the Berberis sp. Several studies have revealed the beneficial effects of berberine in various neurodegenerative disorders. Materials and Methods: T...

Tp53, a stress response gene, is involved in diverse cell death pathways and its activation is implicated in the pathogenesis of Parkinson's disease. However, whether the neuronal Tp53 protein plays a direct role in regulating dopaminergic (DA) neuronal cell death or neuronal terminal damage in different neurotoxicant models is unknown. In our recent studies, in contrast to the global inhibitio...