The objective of this paper is to review and describe the main neuropharmacological changes caused by the chronic use of alcohol and those observed during its withdrawal period. The results show international data referring to the involvement of monoamine systems, neurotransmitters and calcium channels in both neuroadaptation and tolerance to alcohol effects and withdrawal. Relevant studies sho...

Aims: The purpose of this research was to examine the effects methanol-prepared leaf extracts from Solanum americanum Mill. plant on a variety in vitro activities, including antioxidant, anti-Arthritis, anti-inflammatory, thrombolysis, anti-bacterial, and in-vivo neuropharmacological activities.
 Study Design: Methanolic extract (MESAL) primarily evaluated via phytochemical screening. pote...

Article history: Received on: 13/02/2013 Revised on: 15/02/2013 Accepted on: 09/03/2013 Available online: 28/03/2013 Drug addiction presents a chronic relapsing disorder characterized by persistent drug-seeking and taking behaviors. Given the significant detrimental effects of this disease both socially and economically, a considerable research has been dedicated to understanding a number of is...

The traditional method for recording electrophysiological signals from the C. elegans pharynx is called an electropharyngeogram (EPG). It provides an experimental platform for defining gene function, the impact of genetic mutations, and the effects of drugs on the nematode neural network. To date, the EPG has been a low-throughput assay. This paper describes a new microfluidic device that can s...

We investigated the neuropharmacological effects of the methanolic extract from Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory impairment in an Alzheimer's disease (AD) rat model produced by direct intraventricular delivery of amyloid-β1-42 (Aβ1-42). Behavioural assays such as Y-maze and radial arm maze test were used for assessing memory performance. Aβ1-42 decreased ...

Objective: The present study was undertaken to evaluate the possible analgesic, neuropharmacological, anti-diarrheal, and cytotoxic activities of the ethanol extract of leaves of Solanum sisymbriifolium Lam. (Family: Solanaceae). Materials and Methods: The analgesic activity was measured by acetic acid-induced writhing inhibition test. The neuropharmacological activities were evaluated using ho...

We evaluated the neuropharmacological effects of 30% ethanolic pine needle extract (PNE) on memory impairment caused by scopolamine injection in mice hippocampus. Mice were orally pretreated with PNE (25, 50, and 100 mg/kg) or tacrine (10 mg/kg) for 7 days, and scopolamine (2 mg/kg) was injected intraperitoneally, 30 min before the Morris water maze task on first day. To evaluate memory functio...

BACKGROUND The current study was conducted to evaluate the antioxidant, analgesic, antihyperglycemic, neuropharmacological and antidiarrheal activities of ethanolic extract of Lepisanthes rubiginosa L. leaves in different experimental models. METHODS Quantitative and qualitative analysis were done by TLC (thin layer chromatography) and DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scaveng...