In a study of 300 patient episodes where filtration granulocytes or centrifuged granulocytes were transfused to neutropenic patients with fever, 81 cases of culture proven septicemia in patients with acute leukemia were analyzed. Age, sex, organisms, interval between fever and transfusion, average number of transfusion, and antibiotics were similar in the two groups. Centrifuged granulocytes pr...

BACKGROUND Neutropenic fever is one of the most serious adverse effects of cancer chemotherapy. Neutropenia may cause a life-threatening bacterial infection. Therefore, febrile neutropenic inpatients are empirically treated with intravenous broad-spectrum antibiotics. Recently, several studies have suggested the presence of low-risk groups among febrile neutropenic patients. METHODS A prospec...

We observed 71 febrile, neutropenic episodes in 25 oncohematological patients after chemotherapy during a 3-years period from 1995 to 1997. Three patients died because of infections (pneumonia with septic shock, gram-negative bacteremia and sepsis, pseudomembranous colitis and diffuse peritonitis) at the period of prolonged, deep neutropenia (absolute neutrophil count < 100/mm3). During the 71 ...

Background. Neutropenic enterocolitis is one of the most common gastrointestinal complications seen in patients who are receiving chemotherapy for leukemia. Severe neutropenia is the main underlying factor of this pathology. It is characterized by fever and abdominal pain. Case Presentation. Herein, we report a case of neutropenic enterocolitis which presented with intestinal perforation in an ...

Objective: Candidiasis" is the predominant fungal infection that occurs invasively and opportunistically in individuals with compromised immune systems. Febrile neutropenia patients receiving cytotoxic chemotherapy due to malignancy, especially acute leukemia stem cell transplantation are at greater risk among many others. In this study, it was aimed search for Candida DNA make an early diagnos...

Almost forty years ago the relationship between the circulating neutrophil count and the risk of pyogenic infection was established. Since that time, through the vehicle of clinical trials, much has been learnt about the etiologies, risk factors, pathogenesis, and natural history of first and subsequent febrile neutropenic episodes. Refinements to the empirical antibacterial management has redu...

Infection continues to be a leading cause of morbidity and mortality in patients with neoplastic disorders who are treated with myelosuppressive chemotherapy.1 In a granulocytopenic patient, fever may be the first and only sign of infection.2 Other clinical signs and symptoms that often indicate an infectious process may be blunted or missing in the presence of neutropenia. Thus, treating all f...

We report a case of acute lymphoblastic leukemia that was complicated by neutropenic enterocolitis (typhlitis) during the initial period of remission-induction chemotherapy. The patient's clinical symptoms resolved after aggressive treatment with intravenous fluids and electrolytes, nasogastric decompression, bowel rest, total parenteral nutrition, broad-spectrum antibiotics, and granulocyte co...